Publication Name	World Journal of Gastrointestinal Pathophysiology
Manuscript ID	90893
Country	Pakistan

Category	Gastroenterology & Hepatology
Manuscript Type	Observational Study
Article Title	Des-gamma-carboxy prothrombin and alpha-fetoprotein levels as biomarkers for hepatocellular carcinoma and their correlation with radiological characteristics
Manuscript Source	Invited Manuscript
All Author List	Muhammad Ali Qadeer, Zaigham Abbas, Shaima Amjad, Bushra Shahid, Abeer Altaf and Mehreen Siyal
Funding Agency and Grant Number
Corresponding Author	Zaigham Abbas, AGAF, FACG, FACP, FCPS, FRCP, MBBS, Professor, Department of Hepatogastroenterology, Dr. Ziauddin University Hospital Clifton, Street Address, Karachi 75600, Pakistan. drzabbas@gmail.com
Key Words	Des-gamma-carboxy prothrombin; Protein induced by vitamin K absence-II; Cirrhosis; Alpha-fetoprotein; Biomarkers; Hepatocellular carcinoma; Portal vein thrombus
Core Tip	In this prospective study, the performance of des-gamma-carboxy prothrombin (DCP) relative to alpha-fetoprotein (AFP) was assessed in 202 patients diagnosed with hepatocellular carcinoma (HCC). DCP, when used as a standalone marker, exhibited superior diagnostic performance compared to AFP. Combining both tumor markers increased the overall detection rate of HCC, particularly in tumors less than 2 cm in length. Nevertheless, it is recommended that, if a single tumor marker is used, DCP is preferred. The role of DCP as a screening biomarker should be incorporated into the HCC guidelines.
Citation	Qadeer MA, Abbas Z, Amjad S, Shahid B, Altaf A, Siyal M. Des-gamma-carboxy prothrombin and alpha-fetoprotein levels as biomarkers for hepatocellular carcinoma and their correlation with radiological characteristics. World J Gastrointest Pathophysiol 2024; 15(1): 90893

Received	2023-12-16 16:33
Peer-Review Started	2023-12-16 16:33
To Make the First Decision
Return for Revision	2024-01-31 18:22
Revised	2024-02-13 18:43
Second Decision	2024-03-26 01:29
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2024-03-26 04:44
Articles in Press	2024-03-26 04:44
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2024-04-15 02:49

ISSN	2150-5330 (online)
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