Publication Name	World Journal of Critical Care Medicine
Manuscript ID	92458
Country	Greece

Category	Critical Care Medicine
Manuscript Type	Editorial
Article Title	Extracorporeal organ support for critically ill patients: Overcoming the past, achieving the maximum at present, and redefining the future
Manuscript Source	Invited Manuscript
All Author List	Panagiotis Papamichalis, Katerina G Oikonomou, Maria Xanthoudaki, Asimina Valsamaki, Apostolia-Lemonia Skoura, Sophia K Papathanasiou and Achilleas Chovas
Funding Agency and Grant Number
Corresponding Author	Panagiotis Papamichalis, MD, PhD, Consultant Physician-Scientist, Intensive Care Unit, General Hospital of Larissa, 1 Tsakalof, Larissa 41221, Greece. ppapamih@med.uth.gr
Key Words	Kidney-liver replacement therapy; Heart-lung support; Blood purification; Native–artificial organ crosstalk; Multiple organ support therapy; Extracorporeal organ support
Core Tip	Supportive therapy remains the cornerstone of care for critically ill patients. Nowadays, extracorporeal organ support (ECOS) systems have made remarkable technological progress and have become widely available in almost every intensive care unit around the world. Long-lasting multiple organ support therapy is feasible for the kidneys, liver, heart, and lungs, while the use of ECOS systems for suppression of various hyperinflammatory conditions, such as sepsis and coronavirus disease 2019, during cardiac surgery, and after cardiac arrest, is an emerging and rapidly recognized indication. Nowadays, combinations of supportive strategies have been developed tailored to the needs of each patient, leading to new ways of understanding and managing multiple organ failure. Moreover, the crosstalk between native and artificial organs is a novel concept that must be further studied, while further research is needed to clarify the indications, therapeutic protocols, and groups of patients suitable for such therapies.
Citation	Papamichalis P, Oikonomou KG, Xanthoudaki M, Valsamaki A, Skoura AL, Papathanasiou SK, Chovas A. Extracorporeal organ support for critically ill patients: Overcoming the past, achieving the maximum at present, and redefining the future. World J Crit Care Med 2024; In press

Received	2024-01-26 11:34
Peer-Review Started	2024-01-26 11:34
To Make the First Decision
Return for Revision	2024-02-04 05:40
Revised	2024-02-17 11:48
Second Decision	2024-03-26 01:21
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2024-03-26 04:32
Articles in Press	2024-03-26 04:32
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ISSN	2220-3141(online)
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