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4/24/2017 5:26:33 PM | Browse: 274 | Download: 335
Publication Name World Journal of Diabetes
Manuscript ID 31024
Country/Territory United States
Category Endocrinology & Metabolism
Manuscript Type Field of Vision
Article Title Statins redux: A re-assessment of how statins lower plasma cholesterol
Manuscript Source Invited Manuscript
All Author List Rajendra Raghow
Funding Agency and Grant Number
Corresponding Author Rajendra Raghow, PhD, Professor, Department of Veterans Affairs Medical Center, 1030 Jefferson Avenue, Memphis, TN 38104, United States. rraghow@uthsc.edu
Key Words Statins; Atorvastatin; Lovastatin; Rosuvasta­tin; Cholesterol synthesis; Hydroxyl-methyl glutaryl-CoA reductase
Core Tip Schonewille et al, comprehensively studied cholesterol metabolism (de-novo synthesis of cholesterol and its inter-organ flux, and fecal elimination) in mice treated with rosuvastatin, atorvastatin or lovastatin. These analyses revealed that the rates of whole body and organ-specific cholesterol synthesis were boosted by all three statins. Mice treated with statins also elicited enhanced rates of biliary excretion of cholesterol and its fecal elimination. Remarkably, the process of trans-intestinal cholesterol excretion was augmented by only atorvastatin. These data shed mechanistic light on how statin treatment led to organ-specific metabolic adaptations in mice to reset their cholesterol homeostasis.
Citation Raghow R. Statins redux: a re-assessment of how statins lower plasma cholesterol. World J Diabetes 2017; 8(6): 230-234
Received
2016-10-27 10:42
Peer-Review Started
2016-10-31 11:45
To Make the First Decision
2016-12-01 14:26
Return for Revision
2016-12-07 09:56
Revised
2017-04-13 14:51
Second Decision
2017-04-14 10:47
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2017-04-24 17:26
Articles in Press
2017-04-24 17:26
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2017-06-04 07:20
ISSN 1948-9358 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved.
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