Publication Name	World Journal of Psychiatry
Manuscript ID	31280
Country	United Kingdom

Category	Psychiatry
Manuscript Type	Review
Article Title	Understanding the pathophysiology of postpartum psychosis: Challenges and new approaches
Manuscript Source	Invited Manuscript
All Author List	William Davies
Funding Agency and Grant Number	Funding Agency Grant Number Medical Research Council Centre for Neuropsychiatri Genetics and Genomics MR/L010305/1
Corresponding Author	Dr. William Davies, School of Psychology, Cardiff University, Tower Building 70, Park Place, Cardiff CF10 3AT, United Kingdom. daviesw4@cardiff.ac.uk
Key Words	CCN3; Immune system; Steroid sulfatase; Nephroblastoma-overexpressed; Mouse; Animal model; Risk factor
Core Tip	Postpartum psychosis is a severe psychiatric condition affecting a small proportion of women shortly after childbirth. The pathophysiological mechanisms underlying risk for the condition are extremely poorly-defined, but may include perturbed immune function, altered tryptophan metabolism and serotonergic dysfunction. Here, I critically review evidence underlying these assumptions, and discuss a novel model for postpartum psychosis risk, involving maternal deficiency for the enzyme steroid sulfatase, and overexpression of the CCN gene family, based upon emerging data from a recently-developed mouse animal model. Identifying and characterising predictive biomarkers for postpartum psychosis risk will help to ensure prompt clinical inter­vention if required.
Citation	Davies W. Understanding the pathophysiology of postpartum psychosis: Challenges and new approaches. World J Psychiatr 2017; 7(2): 77-88

Received	2016-11-08 10:03
Peer-Review Started	2016-11-10 11:23
To Make the First Decision	2017-01-14 10:37
Return for Revision	2017-01-20 17:46
Revised	2017-01-25 23:06
Second Decision	2017-04-10 17:59
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2017-04-20 08:37
Articles in Press	2017-04-20 08:37
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2017-06-06 06:52

ISSN	2220-3206 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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