Publication Name	World Journal of Hepatology
Manuscript ID	31439
Country	Japan

Category	Gastroenterology & Hepatology
Manuscript Type	Retrospective Study
Article Title	Image quality and diagnostic performance of free-breathing diffusion-weighted imaging for hepatocellular carcinoma
Manuscript Source	Invited Manuscript
All Author List	Yukihisa Takayama, Akihiro Nishie, Yoshiki Asayama, Kousei Ishigami, Daisuke Kakihara, Yasuhiro Ushijima, Nobuhiro Fujita, Ken Shirabe, Atsushi Takemura and Hiroshi Honda
Funding Agency and Grant Number
Corresponding Author	Akihiro Nishie, MD, PhD, Associated professor, Department of Clinical Radiology, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan. anishie@radiol.med.kyushu-u.ac.jp
Key Words	diffusion weighted-imaging; liver; magnetic resonance imaging; hepatocellular carcinoma; free-breathing technique
Core Tip	This retrospective study evaluated the image quality of free-breathing diffusion-weighted imaging (FB-DWI) of the liver and its diagnostic performance for hepatocellular carcinoma compared with respiratory-triggered DWI. The free-breathing technique is widely believed to be inappropriate for body DWI because motion artifact causes decreased image quality. How­ever, after a modification of imaging parameters, FB-DWI showed better image quality without significantly reducing the signal-to-noise ratio of the normal liver parenchyma and the lesion-to-nonlesion contrast-to-noise ratio com­pared to respiratory-triggering-DWI. As a result, the improvement of the image quality of FB-DWI contributed to an increased rate of detection of hepatocellular carcinoma.
Citation	Takayama Y, Nishie A, Asayama Y, Ishigami K, Kakihara D, Ushijima Y, Fujita N, Shirabe K, Takemura A, Honda H. Image quality and diagnostic performance of free-breathing diffusion-weighted imaging for hepatocellular carcinoma. World J Hepatol 2017; 9(14): 657-666

Received	2016-11-17 08:58
Peer-Review Started	2016-11-17 17:15
To Make the First Decision	2017-02-04 14:28
Return for Revision	2017-02-09 10:59
Revised	2017-02-11 14:57
Second Decision	2017-04-14 10:48
Accepted by Journal Editor-in-Chief	2017-04-14 11:36
Accepted by Company Editor-in-Chief	2017-04-24 17:29
Articles in Press	2017-04-24 17:29
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2017-05-15 00:24

ISSN	1948-5182 (online)
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