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Publication Name World Journal of Diabetes
Manuscript ID 28682
Country/Territory India
Received
2016-07-11 09:22
Peer-Review Started
2016-07-14 18:24
To Make the First Decision
2016-09-06 11:05
Return for Revision
2016-09-12 15:27
Revised
2016-09-26 22:52
Second Decision
2016-11-10 14:23
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2016-11-22 15:35
Articles in Press
2016-11-22 15:35
Publication Fee Transferred
Edit the Manuscript by Language Editor
2016-12-21 14:51
Typeset the Manuscript
2017-03-07 09:28
Publish the Manuscript Online
2017-03-09 16:09
ISSN 1948-9358 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Medicine, Research & Experimental
Manuscript Type Prospective Study
Article Title Role of angiotensin converting enzyme and angiotensinogen gene polymorphisms in angiotensin converting enzyme inhibitor-mediated antiproteinuric action in type 2 diabetic nephropathy patients
Manuscript Source Invited Manuscript
All Author List Neerja Aggarwal, Pawan Kumar Kare, Parul Varshney, Om Prakash Kalra, Sri Venkata Madhu, Basu Dev Banerjee, Anil Yadav, Alpana Raizada and Ashok Kumar Tripathi
Funding Agency and Grant Number
Funding Agency Grant Number
Department of Biotechnology, Government of India, New Delhi (DBT Project) BT/PR 4640/MED/30/716/2012
Corresponding Author Ashok Kumar Tripathi, PhD, Professor, Biochemistry and Immunology Laboratory, Department of Biochemistry, University College of Medical Sciences (University of Delhi) and Guru Teg Bahadur Hospital, Dilshad Garden, Delhi 110095, India. aktripathiucms@gmail.com
Key Words Diabetic nephropathy; Angiotensin converting enzyme inhibitor therapy; Renin-angiotensin-aldosterone system gene polymorphisms; Responder; Urinary albumin/creatinine ratio; Albuminuria
Core Tip Angiotensin converting enzyme (ACE) inhibitors are used as standard therapy in patients with diabetic nephropathy (DN) and reported to have reno-protective effect in these patients; however, the response to ACE inhibitor therapy is not uniform in all patients. We investigated whether ACE I/D and angiotensinogen gene (AGT) M235T polymorphisms of genes of the renin-angiotensin-aldosterone system are associated with variable response to ACE inhibitors in DN patients. ACE inhibitor treatment in DN patients caused a significant reduction in urinary protein excretion and was found independent of ACE I/D and AGT M235T polymorphisms.
Publish Date 2017-03-09 16:09
Citation Aggarwal N, Kare PK, Varshney P, Kalra OP, Madhu SV, Banerjee BD, Yadav A, Raizada A, Tripathi AK. Role of angiotensin converting enzyme and angiotensinogen gene polymorphisms in angiotensin converting enzyme inhibitor-mediated antiproteinuric action in type 2 diabetic nephropathy patients. World J Diabetes 2017; 8(3): 112-119
URL http://www.wjgnet.com/1948-9358/full/v8/i3/112.htm
DOI http://dx.doi.org/10.4239/wjd.v8.i3.112
Full Article (PDF) WJD-8-112.pdf
Full Article (Word) WJD-8-112.doc
Manuscript File 28682-Review.docx
Answering Reviewers 28682-Answering reviewers.pdf
Audio Core Tip 28682-Audio core tip.mp3
Biostatistics Review Certificate Biostatistics_Statement_20160710165641.pdf
Clinical Trial Registration Statement DeclarationOf_HelsinkiConformation_Statement_20160710170410.pdf
Conflict-of-Interest Disclosure Form 28682-Conflict-of-interest statement.pdf
Copyright License Agreement 28682-Copyright assignment.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s) 28682-Grant application form(s).pdf
Signed Informed Consent Form(s) or Document(s) Informed_Consent_Statement_20160710165855.pdf
Institutional Review Board Approval Form or Document 28682-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate 28682-Language certificate.pdf
Peer-review Report 28682-Peer-review(s).pdf
Scientific Misconduct Check 28682-Scientific misconduct check.pdf
Scientific Editor Work List 28682-Scientific editor work list.pdf