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3/9/2017 5:20:00 PM | Browse: 771 | Download: 1775
Publication Name World Journal of Diabetes
Manuscript ID 31044
Country/Territory United Kingdom
Received
2016-10-27 21:22
Peer-Review Started
2016-10-31 15:35
To Make the First Decision
2016-12-01 14:31
Return for Revision
2016-12-05 13:37
Revised
2016-12-14 17:36
Second Decision
2016-12-20 15:41
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2017-01-03 15:37
Articles in Press
2017-01-03 15:37
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2017-03-07 09:28
Publish the Manuscript Online
2017-03-09 16:09
ISSN 1948-9358 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Endocrinology & Metabolism
Manuscript Type Retrospective Cohort Study
Article Title Statin, testosterone and phosphodiesterase 5-inhibitor treatments and age related mortality in diabetes
Manuscript Source Invited Manuscript
All Author List Geoffrey Hackett, Peter W Jones, Richard C Strange and Sudarshan Ramachandran
Funding Agency and Grant Number
Funding Agency Grant Number
Bayer plc to University of Bedfordshire BSP-SOP-040
Corresponding Author Sudarshan Ramachandran, PhD, FRC Path, Professor, Department of Clinical Biochemistry, Heart of England NHS Foundation Trust, Good Hope Hospital, Rectory Road, Sutton Coldfield, West Midlands B75 7RR, United Kingdom. sud.ramachandran@heartofengland.nhs.uk
Key Words Type 2 diabetes; Mortality; Gompertz-Makeham equation; Phosphodiesterase 5 inhibitors; Male hypogonadism; Statins; Testosterone replacement therapy
Core Tip We have described a study of men with type 2 diabetes showing that mortality rates are in accordance with the pattern described nearly 200 years ago by Benjamin Gompertz. The data show that statin, phosphodiesterase 5 inhibitors (PDE5I) and testosterone replacement in hypogonadal men reduce all-cause mortality. PDE5I, alone and in combination with the other 2 agents alters the association between age and mortality, thus improving prognosis. The graphical illustrations adopted in this paper communicate the impact of medical intervention very effectively to patients and this could potentially improve compliance leading to significant clinical benefit.
Publish Date 2017-03-09 16:09
Citation Hackett G, Jones PW, Strange RC, Ramachandran S. Statin, testosterone and phosphodiesterase 5-inhibitor treatments and age related mortality in diabetes. World J Diabetes 2017; 8(3): 104-111
URL http://www.wjgnet.com/1948-9358/full/v8/i3/104.htm
DOI http://dx.doi.org/10.4239/wjd.v8.i3.104
Full Article (PDF) WJD-8-104.pdf
Full Article (Word) WJD-8-104.doc
Manuscript File 31044-Review.docx
Answering Reviewers 31044-Answering reviewers.pdf
Audio Core Tip 31044-Audio core tip.mp3
Biostatistics Review Certificate 31044-Biostatistics statement.pdf
Clinical Trial Registration Statement 31044-Clinical trial registration statement.pdf
Conflict-of-Interest Disclosure Form 31044-Conflict-of-interest statement.pdf
Copyright License Agreement 31044-Copyright assignment.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s) 31044-Grant application form(s).pdf
Signed Informed Consent Form(s) or Document(s) 31044-Clinical trial registration statement.pdf
Institutional Review Board Approval Form or Document 31044-Institutional review board statement.pdf
Peer-review Report 31044-Peer-review(s).pdf
Scientific Misconduct Check 31044-Scientific misconduct check.pdf
Scientific Editor Work List 31044-Scientific editor work list.pdf