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Articles Published Processes
8/26/2014 11:20:00 AM | Browse: 953 | Download: 864
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Received |
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2014-03-28 10:45 |
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Peer-Review Started |
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2014-03-31 10:34 |
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To Make the First Decision |
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2014-04-28 14:33 |
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Return for Revision |
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2014-04-30 16:02 |
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Revised |
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2014-05-10 22:07 |
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Second Decision |
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2014-06-27 17:39 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Company Editor-in-Chief |
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2014-06-27 17:53 |
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Articles in Press |
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2014-06-27 18:13 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2014-07-21 15:15 |
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Publish the Manuscript Online |
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2014-07-27 18:55 |
Category |
Immunology |
Manuscript Type |
Review |
Article Title |
Targeting TLR4/MAPKs signaling pathway: A better option for therapeutic inhibition of atherosclerosis
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Manuscript Source |
Invited Manuscript |
All Author List |
Janeesh Plakkal Ayyappan and Annie Abraham |
Funding Agency and Grant Number |
Funding Agency |
Grant Number |
University of Kerala, India for the study |
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Corresponding Author |
Dr. Annie Abraham, Director, Professor of Biochemistry, Department of Biochemistry, School of Life sciences, University of Kerala, Palayam Airport Road, Kariavattom Campus 695 581, India. annieab2001@gmail.com |
Key Words |
Atherosclerosis; Toll-like receptor 4; Mitogen activated protein kinase; Foam cells; Inflammatory markers |
Core Tip |
The inhibition of atherosclerosis is one of primary target for the therapeutics of cardiovascular diseases, which is the eminent health problem worldwide. The important function of toll-like receptor 4 (TLR4) in the activation and progression of atherosclerosis is justified here. The TLR4 in turn activates the mitogen activated protein kinase (MAPKs) and nuclear factor kappa-light-chain-enhancer of activated B cells which are responsible for most of the inflammatory events. Hence, therapeutic inhibition of TLR4/MAPKS signaling pathway is one of the best method of inhibiting atherosclerosis. |
Publish Date |
2014-07-27 18:55 |
Citation |
Plakkal Ayyappan J, Abraham A. Targeting TLR4/MAPKs signaling pathway: A better option for therapeutic inhibition of atherosclerosis. World J Immunol 2014; 4(2): 116-121 |
URL |
http://www.wjgnet.com/2219-2824/full/v4/i2/116.htm |
DOI |
http://dx.doi.org/10.5411/wji.v4.i2.116 |
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