| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Randomized Clinical Trial |
| Article Title |
Clinical trial with traditional Chinese medicine intervention ''tonifying the kidney to promote liver regeneration and repair by affecting stem cells and their microenvironment'' for chronic hepatitis B-associated liver failure
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Han-Min Li, Zhi-Hua Ye, Jun Zhang, Xiang Gao, Yan-Ming Chen, Xin Yao, Jian-Xun Gu, Lei Zhan, Yang Ji, Jian-Liang Xu, Ying-He Zeng, Fan Yang, Lin Xiao, Guo-Guang Sheng, Wei Xin, Qi Long, Qing-Jing Zhu, Zhao-Hong Shi, Lian-Guo Ruan, Jia-Yao Yang, Chang-Chun Li, Hong-Bin Wu, Sheng-Duo Chen and Xin-La Luo |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Science and Technology Key Projects on “Major Infectious Diseases such as HIV/AIDS, Viral Hepatitis Prevention and Treatment” |
2008ZX10005-007 |
| Research Projects of Key Disease of National Traditional Chinese Medicine (Hepatopathy) Clinical Research Center (Hubei Province) |
JDZX2012054 |
| National Natural Science Foundation of China |
81373513 |
| National Natural Science Foundation of China |
90709041 |
| National Natural Science Foundation of China |
30672590 |
| National Natural Science Foundation of China |
30271562 |
| National Natural Science Foundation of China |
30371787 |
| National Natural Science Foundation of China |
81102531 |
| National Natural Science Foundation of China |
81274147 |
| Key Projects of Natural Science Foundation of Hubei Province |
2011CDB463 |
| Specialized Research Fund for the Doctoral Programs in Institution of Higher Education |
20124230110001 |
| Key Subjects of Department of Science and Technology of Wuhan City |
201260523199 |
|
| Corresponding Author |
Han-Min Li, MD, PhD, Professor, Hepatopathy Institute, Affiliated Hospital of Hubei University of Chinese Medicine, Huayuan No. 4, Wuchang District, Wuhan 430061, Hubei Province, China. lihanmin69@126.com |
| Key Words |
Clinical study; “Tonifying the kidney to promote liver regeneration and repair by affecting stem cells and their microenvironment” (“TTK”); Liver regeneration; Treatment with integrated traditional and Western medicine; Chronic hepatitis b-associated liver failure |
| Core Tip |
We conducted a randomized controlled clinical trial to observe the effects of traditional Chinese medicine intervention “tonifying the kidney to promote liver regeneration and repair by affecting stem cells and their microenvironment” (“TTK”) in treating liver failure due to chronic hepatitis B virus infection. The fatality rate in the group treated with “TTK” was significantly lower than those in the other two groups (16.67% vs 51.61%, 35.38%, P = 0.010). The mechanism for this effect may be related to promotion of liver regeneration and repair through affecting stem cells and their microenvironment. |
| Publish Date |
2015-01-06 09:08 |
| Citation |
Li HM, Ye ZH, Zhang J, Gao X, Chen YM, Yao X, Gu JX, Zhan L, Ji Y, Xu JL, Zeng YH, Yang F, Xiao L, Sheng GG, Xin W, Long Q, Zhu QJ, Shi ZH, Ruan LG, Yang JY, Li CC, Wu HB, Chen SD, Luo XL. Clinical trial with traditional Chinese medicine intervention ‘‘tonifying the kidney to promote liver regeneration and repair by affecting stem cells and their microenvironment’’ for chronic hepatitis B-associated liver failure. World J Gastroenterol 2014; 20(48): 18458-18465 |
| URL |
http://www.wjgnet.com/1007-9327/full/v20/i48/18458.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v20.i48.18458 |
