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Articles Published Processes
12/18/2014 5:08:00 PM | Browse: 820 | Download: 994
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Received |
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2014-04-23 20:34 |
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Peer-Review Started |
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2014-04-24 20:29 |
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To Make the First Decision |
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2014-05-29 19:20 |
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Return for Revision |
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2014-06-05 19:33 |
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Revised |
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2014-06-17 15:48 |
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Second Decision |
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2014-08-28 10:00 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Company Editor-in-Chief |
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2014-08-28 10:33 |
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Articles in Press |
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2014-08-28 10:56 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2014-11-25 09:30 |
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Publish the Manuscript Online |
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2014-12-18 17:08 |
Category |
Gastroenterology & Hepatology |
Manuscript Type |
Letter to the Editor |
Article Title |
Reversal of IgM deficiency following a gluten-free diet in seronegative celiac disease
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Manuscript Source |
Unsolicited Manuscript |
All Author List |
Lucia Montenegro, Domenico Piscitelli, Floriana Giorgio, Claudia Covelli, Maria Grazia Fiore, Giuseppe Losurdo, Andrea Iannone, Enzo Ierardi, Alfredo Di Leo and Mariabeatrice Principi |
Funding Agency and Grant Number |
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Corresponding Author |
Alfredo Di Leo, Professor, Gastroenterology Unit, Policlinico Hospital, Piazza G Cesare 11, 70124 Bari, Italy. alfredo.dileo@uniba.it |
Key Words |
Selective IgM deficiency; Seronegative celiac disease; Tissue transglutaminase; Gluten-free diet |
Core Tip |
Selective IgM deficiency is a rare condition, associated in 5% of cases to Celiac Disease (CD). The CD diagnosis in patients with immunoglobulin deficiencies is based only on response to a Gluten-Free Diet (GFD). Deposits of tissue transglutaminase are found in duodenal samples of seronegative CD. Our case (IgM deficiency/seronegative CD) disclosed novel insights: (1) it is possible to observe a selective association of IgM deficiency/seronegative CD; (2) the histological diagnosis of CD may be complex due to poor lymphocyte maturation; (3) mRNA coding for tissue transglutaminase in duodenal mucosa could be a useful diagnostic tool; and (4) GFD may reverse IgM deficiency by promoting lymphocyte maturation. |
Publish Date |
2014-12-18 17:08 |
Citation |
Montenegro L, Piscitelli D, Giorgio F, Covelli C, Fiore MG, Losurdo G, Iannone A, Ierardi E, Di Leo A, Principi M. Reversal of IgM deficiency following a gluten-free diet in seronegative celiac disease. World J Gastroenterol 2014; 20(46): 17686-17689 |
URL |
http://www.wjgnet.com/1007-9327/full/v20/i46/17686.htm |
DOI |
http://dx.doi.org/10.3748/wjg.v20.i46.17686 |
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