| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Observational Study |
| Article Title |
Insulin resistance and steatosis in HBV-HCV co-infected patients: Role of PNPLA3 polymorphisms and impact on liver fibrosis progression
|
| Manuscript Source |
Invited Manuscript |
| All Author List |
Rosa Zampino, Nicola Coppola, Grazia Cirillo, Adriana Boemio, Carmine Minichini, Aldo Marrone, Maria Stanzione, Mario Starace, Emanuele Durante-Mangoni, Evangelista Sagnelli, Luciano Restivo, Giovanna Salzillo, Maria Chiara Fascione, Riccardo Nevola, Emanuele Miraglia del Giudice and Luigi Elio Adinolfi |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Regione Campania, Italy |
|
|
| Corresponding Author |
Luigi Elio Adinolfi, MD, Professor, Clinical Hospital of Marcianise, ASL Caserta, Rione Santella, 81025 Marcianise (CE), Italy. luigielio.adinolfi@unina2.it
|
| Key Words |
Steatosis; Insulin resistance; Hepatitis B and C viruses co-infection; Patatin-like phospholipase domain-containing 3; Liver fibrosis |
| Core Tip |
We evaluated the prevalence and role of steatosis, insulin resistance and patatin-like phospholipase domain-containing 3 (PNPLA3) polymorphisms on disease progression in hepatitis B and C viruses (HCV-HBV) co-infected patients. The data showed that HBV-HCV patients have lower levels of liver steatosis and insulin resistance than HCV mono-infected patients. HBV seems to interact with HCV reducing HCV replication and HCV-related metabolic features. Thus, the influence of HCV-related steatosis and insulin resistance as well as PNPLA3 polymorphism do not significantly impact liver fibrosis progression in HBV-HCV patients. The more rapid progression of liver fibrosis observed in HBV-HCV co-infected patients seems to be mostly associated with HBV infection.
|
| Publish Date |
2014-10-19 20:39 |
| Citation |
Zampino R, Coppola N, Cirillo G, Boemio A, Minichini C, Marrone A, Stanzione M, Starace M, Durante-Mangoni E, Sagnelli E, Restivo L, Salzillo G, Fascione MC, Nevola R, del Giudice EM, Adinolfi LE. Insulin resistance and steatosis in HBV-HCV co-infected patients: Role of PNPLA3 polymorphisms and impact on liver fibrosis progression. World J Hepatol 2014; 6(9): 677-684 |
| URL |
http://www.wjgnet.com/1948-5182/full/v6/i9/677.htm |
| DOI |
http://dx.doi.org/10.4254/wjh.v6.i9.677 |
