Publication Name	World Journal of Gastroenterology
Manuscript ID	11501
Country	China

Received	2014-05-24 12:03
Peer-Review Started	2014-05-24 12:09
To Make the First Decision	2014-07-15 11:03
Return for Revision	2014-07-16 11:37
Revised	2014-08-16 11:42
Second Decision	2014-09-19 09:17
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2014-09-19 10:12
Articles in Press	2014-09-19 10:34
Publication Fee Transferred
Edit the Manuscript by Language Editor	2014-10-21 08:49
Typeset the Manuscript	2014-12-11 10:56
Publish the Manuscript Online	2014-12-20 19:42

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
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Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Autobiography
Article Title	Micro-RNA-185 regulates the expression of lipid metabolism genes and improves insulin-sensitivity in C57Bl/6 mice with non-alcoholic fatty liver disease
Manuscript Source	Unsolicited Manuscript
All Author List	Xiao-Chen Wang, Xiao-Rong Zhan, Xin-Yu Li, Jun-Jie Yu and Xiao-Min Liu
Funding Agency and Grant Number	Funding Agency Grant Number National Natural Science Foundation of China 30950005 Department of Education of Heilongjiang Province 12511233
Corresponding Author	Xiao-Min Liu, MD, Professor, Department of Endocrinology, First Hospital of Harbin Medical University, No. 199 Dongdazhi Street, Nangang District, Harbin 150001, Heilongjiang Province, China. liuxiaomin2013a@163.com
Key Words	MiR-185; Insulin-signalling pathway; Lipid metabolism; Non-alcoholic fatty liver disease
Core Tip	Our study presents important information on the pathogenesis of non-alcoholic fatty liver disease (NAFLD) and insulin resistance. We used a Bioinformatics method to identify microRNAs potentially involved in the regulation of lipid metabolism and insulin signalling. We chose micro-RNA-185 (miR-185) to validate in vitro and in vivo in regard to regulation of lipid metabolism gene expression and blockade of the insulin-signalling pathway. We found over-expression of miR-185 improved insulin sensitivity and reduced liver steatosis in a NAFLD animal model. No previous studies have reported miR-185 regulation of the insulin-signalling pathway. MiR-185 might be useful in the design of therapeutic strategies for treating NAFLD and insulin resistance.
Publish Date	2014-12-20 19:42
Citation	Wang XC, Zhan XR, Li XY, Yu JJ, Liu XM. MicroRNA-185 regulates expression of lipid metabolism genes and improves insulin sensitivity in mice with non-alcoholic fatty liver disease. World J Gastroenterol 2014; 20(47): 17914-17923
URL	http://www.wjgnet.com/1007-9327/full/v20/i47/17914.htm
DOI	http://dx.doi.org/10.3748/wjg.v20.i47.17914

Full Article (PDF)	WJG-20-17914.pdf
Full Article (Word)	WJG-20-17914.doc
Manuscript File	11501-Review.doc
Answering Reviewers	11501-Answering reviewers.pdf
Copyright License Agreement	11501-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate	11501-Language certificate.pdf
Peer-review Report	11501-Peer review(s).pdf
Scientific Misconduct Check	11501-CrossCheck.jpg
Scientific Editor Work List	11501-Scientific editor work list.pdf