| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Autobiography |
| Article Title |
Resistant mutants induced by adefovir dipivoxil in hepatitis B virus isolates
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Su-Wen Jiang, Li-Peng Yao, Ai-Rong Hu, Yao-Ren Hu, Shi-Xiang Chen, Tao Xiong, Guo-Sheng Gao, Xiao-Yue Liang, Shi-Xiong Ding and Peng-Jian Weng |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| BaoenWang Liver Fibrosis Research Fund of the Chinese Foundation for Hepatitis Prevention and Control |
20100009 |
| Zhejiang Medicine and Health Sciences Research Fund |
2008B167 |
| Zhejiang Medicine and Health Sciences Research Fund |
2014PYA018 |
| Nanjing Military Area Command of the PLA Medical Technology Innovation |
11MA019 |
| Ningbo Health Technology Project for Excellent Young and Middle-aged Talent |
2011-145 |
| Ningbo Leader and Top Notch Person Training Project |
2012-131 |
| Zhejiang Medicine and Health Project for Excellent Young Talent |
2013-245 |
|
| Corresponding Author |
Ai-Rong Hu, MD, Institute of Liver Diseases, Ningbo No. 2 Hospital, 41 Xibei Street, Haishu District, Ningbo 315010, Zhejiang Province, China. huairong6666@126.com |
| Key Words |
Hepatitis B virus; Adefovir dipivoxil; Drug-resistant mutant; Gene sequencing |
| Core Tip |
Currently, hepatitis B virus (HBV) resistance to adefovir dipivoxil (ADV) has become more prevalent. However, it is not known whether drug-resistant HBV mutants induced by ADV are related to the clinical features of patients. In this study, we analyzed the exhaustive resistant mutants induced by ADV. Of 79 patients, 26 (32.9%) had more than two loci of drug resistance in HBV mutants. Because drug-resistant HBV mutants induced by ADV are complicated and diverse, we conclude that testing for resistant mutants prior to antiviral treatment, administering standard and first-line antiviral treatment, and personalizing medication according to the clinical characteristics of patients is important to avoid subsequent noncompliance and the need for salvage treatment. |
| Publish Date |
2014-12-10 15:52 |
| Citation |
Jiang SW, Yao LP, Hu AR, Hu YR, Chen SX, Xiong T, Gao GS, Liang XY, Ding SX, Weng PJ. Resistant mutants induced by adefovir dipivoxil in hepatitis B virus isolates. World J Gastroenterol 2014; 20(45): 17100-17106 |
| URL |
http://www.wjgnet.com/1007-9327/full/v20/i45/17100.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v20.i45.17100 |
