Publication Name	World Journal of Stem Cells
Manuscript ID	12861
Country	Thailand

Received	2014-07-28 10:31
Peer-Review Started	2014-07-28 19:21
To Make the First Decision	2014-09-16 10:50
Return for Revision	2014-09-18 10:24
Revised	2014-10-01 21:23
Second Decision	2014-10-29 17:59
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2014-10-29 18:55
Articles in Press	2014-10-29 18:55
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2014-12-22 16:29
Publish the Manuscript Online	2015-01-14 11:53

ISSN	1948-0210 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
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Website	http://www.wjgnet.com

Category	Oncology
Manuscript Type	Review
Article Title	Epigenetic therapy of cancer stem and progenitor cells by targeting DNA methylation machineries
Manuscript Source	Invited Manuscript
All Author List	Patompon Wongtrakoongate
Funding Agency and Grant Number
Corresponding Author	Patompon Wongtrakoongate, PhD, Department of Biochemistry, Faculty of Science, Mahidol University, Rama VI Road, Bangkok 10400, Thailand. p.wongtrakoongate@gmail.com
Key Words	Cancer stem and progenitor cells; DNA methylation; Epigenetic therapy; Aza-cytidine; Aza-deoxycytidine
Core Tip	Several types of cancers can be developed from genetic and/or epigenetic instabilities of stem and progenitor cells. Epigenetic abnormality involving dysregulation of DNA methylation has been reported to implicate in cancer aggressiveness. Inhibition of DNA methyltransferase activity by DNA methylation inhibitors has shown promising results toward treatment of myelodysplastic syndrome, a disease associated with leukemic stem cells. This review summarizes evidences which are pertinent to the antitumorigenic potential of DNA methylation inhibitors 5-Azacytidine and 5-Aza-2’-deoxycytidine on cancer stem and progenitor cells including those of leukemia and other solid tumors.
Publish Date	2015-01-14 11:53
Citation	Wongtrakoongate P. Epigenetic therapy of cancer stem and progenitor cells by targeting DNA methylation machineries. World J Stem Cells 2015; 7(1): 137-148
URL	http://www.wjgnet.com/1948-0210/full/v7/i1/137.htm
DOI	http://dx.doi.org/10.4252/wjsc.v7.i1.137

Full Article (PDF)	WJSC-7-137.pdf
Full Article (Word)	WJSC-7-137.doc
Manuscript File	12861-Review.doc
Answering Reviewers	12861-Answering reviewers.pdf
Copyright License Agreement	12861-Copyright assignment.pdf
Peer-review Report	12861-Peer review(s).pdf
Scientific Misconduct Check	12861-CrossCheck.jpg
Scientific Editor Work List	12861-Scientific editor work list.pdf