Publication Name	World Journal of Hepatology
Manuscript ID	13545
Country	Austria

Received	2014-08-27 08:46
Peer-Review Started	2014-08-27 14:38
To Make the First Decision	2014-11-27 12:24
Return for Revision	2014-12-02 16:08
Revised	2014-12-12 17:38
Second Decision	2014-12-26 08:38
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2014-12-31 13:20
Articles in Press	2014-12-31 13:20
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2015-01-27 17:32
Publish the Manuscript Online	2015-02-13 09:30

ISSN	1948-5182 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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Category	Gastroenterology & Hepatology
Manuscript Type	Topic Highlights
Article Title	Dysregulation of iron and copper homeostasis in nonalcoholic fatty liver
Manuscript Source	Invited Manuscript
All Author List	Elmar Aigner, Günter Weiss and Christian Datz
Funding Agency and Grant Number	Funding Agency Grant Number PMU-Forschungsförderungsfonds E-13/17/086-AIG Austrian Research Funds, FWF, Project TRP-188 to Weiss G SPAR Austria to Christian Datz
Corresponding Author	Elmar Aigner, MD, First Department of Medicine, Paracelsus Private Medical University Salzburg, Müllner Hauptstrasse 48, 5020 Salzburg, Austria. e.aigner@salk.at
Key Words	Dysmetabolic iron overload syndrome; Hepcidin; Iron overload; Metabolic syndrome; Non-alcoholic fatty liver disease; Nonalcoholic steatohepatitis
Core Tip	Hyperferritinemia with normal transferrin saturation and mostly mild hepatic iron deposition is a frequent finding in subjects with non-alcoholic fatty liver disease. Excess iron in non-alcoholic fatty liver disease (NAFLD) patients is referred to as the “dysmetabolic iron overload syndrome”. Clinical evidence suggests that elevated body iron stores aggravate the clinical course of NAFLD with regard to liver-related and extrahepatic disease complications. Iron removal improves insulin sensitivity, delays the onset of type 2 diabetes mellitus, improves pathologic liver function tests and ameliorates NAFLD histology The mechanisms contributing to iron excess in fatty liver include impaired iron export from hepatocytes and mesenchymal Kupffer.
Publish Date	2015-02-13 09:30
Citation	Aigner E, Weiss G, Datz C. Dysregulation of iron and copper homeostasis in nonalcoholic fatty liver. World J Hepatol 2015; 7(2): 177-188
URL	http://www.wjgnet.com/1948-5182/full/v7/i2/177.htm
DOI	http://dx.doi.org/10.4254/wjh.v7.i2.177

Full Article (PDF)	WJH-7-177.pdf
Full Article (Word)	WJH-7-177.doc
Manuscript File	13545-Review.docx
Answering Reviewers	13545-Answering reviewers.pdf
Conflict-of-Interest Disclosure Form	13545-Conflict-of-interest statement.pdf
Copyright License Agreement	13545-Copyright assignment.pdf
Peer-review Report	13545-Peer review(s).pdf
Scientific Misconduct Check	13545-CrossCheck.jpg
Scientific Editor Work List	13545-Scientific editor work list.pdf