| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
|
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Prospective Study |
| Article Title |
Boceprevir early-access for advanced-fibrosis/cirrhosis in Asia-pacific hepatitis C virus genotype 1 non-responders/relapsers
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Wattana Sukeepaisarnjaroen, Tri Pham, Tewesak Tanwandee, Saroja Nazareth, Sam Galhenage, Lindsay Mollison, Leanne Totten, Alan Wigg, Rosalie Altus, Anton Colman, Brenda Morales, Sue Mason, Tracey Jones, Nadine Leembruggen, Vince Fragomelli, Cheryl Sendall, Richard Guan, Dede Sutedja, Soek Siam Tan, Yock Young Dan, Yin Mei Lee, Widjaja Luman, Eng Kiong Teo, Yin Min Than, Teerha Piratvisuth and Seng Gee Lim |
| Funding Agency and Grant Number |
|
| Corresponding Author |
Seng Gee Lim, MBBS, MD, FRCP, FRACP, FAMS, Director, Department of Gastroenterology and Hepatology, National University Health System, 1E Lower Kent Ridge Road, Singapore 119228, Singapore. mdclimsg@nus.edu.sg |
| Key Words |
Chronic hepatitis C; Treatment failure; Rapid virological response; Lead-in; Null response; Partial response; Relapse; Cirrhosis; Response guided therapy |
| Core Tip |
This is the first report of boceprevir, PEGylated interferon and ribavirin in PEGylated interferon treatment failures in the Asia-Pacific and showed an overall sustained virological response at week 12 (SVR12) of 61%. Asians were compared with Caucasians and had similar SVR12 results: Asians 59.3% and Caucasians 63.5%. On-treatment responses at week 4, 8 and 12 predicted SVR12. Multivariate analysis showed that treatment week 8 and 12 were independent predictors of SVR12. Serious adverse events occurred in 18.6%, comprising sepsis (2%), decompensation (2.7%) and blood transfusion (14%). Discontinuations occurred in 30.7%. |
| Publish Date |
2015-07-30 11:17 |
| Citation |
Sukeepaisarnjaroen W, Pham T, Tanwandee T, Nazareth S, Galhenage S, Mollison L, Totten L, Wigg A, Altus R, Colman A, Morales B, Mason S, Jones T, Leembruggen N, Fragomelli V, Sendall C, Guan R, Sutedja D, Tan SS, Dan YY, Lee YM, Luman W, Teo EK, Than YY, Piratvisuth T, Lim SG. Boceprevir early-access for advanced-fibrosis/cirrhosis in Asia-pacific hepatitis C virus genotype 1 non-responders/relapsers. World J Gastroenterol 2015; 21(28): 8660-8669 |
| URL |
http://www.wjgnet.com/1007-9327/full/v21/i28/8660.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v21.i28.8660 |
