Publication Name	World Journal of Gastroenterology
Manuscript ID	15017
Country	Japan

Received	2014-11-04 19:14
Peer-Review Started	2014-11-07 15:02
To Make the First Decision	2014-12-11 20:25
Return for Revision	2014-12-15 17:27
Revised	2014-12-18 16:42
Second Decision	2015-01-08 13:17
Accepted by Journal Editor-in-Chief	2015-01-08 20:13
Accepted by Company Editor-in-Chief	2015-01-21 17:06
Articles in Press	2015-01-21 17:30
Publication Fee Transferred
Edit the Manuscript by Language Editor	2015-02-11 22:51
Typeset the Manuscript	2015-05-08 11:31
Publish the Manuscript Online	2015-05-30 13:32

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
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Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Retrospective Study
Article Title	Laboratory test variables useful for distinguishing upper from lower gastrointestinal bleeding
Manuscript Source	Unsolicited Manuscript
All Author List	Minoru Tomizawa, Fuminobu Shinozaki, Rumiko Hasegawa, Yoshinori Shirai, Yasufumi Motoyoshi, Takao Sugiyama, Shigenori Yamamoto and Naoki Ishige
Funding Agency and Grant Number
Corresponding Author	Minoru Tomizawa, MD, PhD, Department of Gastroenterology, National Hospital Organization Shimoshizu Hospital, 934-5 Shikawatashi, Yotsukaido City, Chiba 284-0003, Japan. nihminor-cib@umin.ac.jp
Key Words	Logistic regression analysis; Likelihood analysis; Receiver-operator characteristic analysis; Blood urine nitrogen; Hemoglobin
Core Tip	Differentiation of upper vs lower gastrointestinal (GI) bleeding is crucial. Laboratory test variables were investigated for their ability to distinguish upper from lower GI bleeding from retrospective analysis. Total protein, hemoglobin, and lactate dehydrogenase were lower and blood urea nitrogen (BUN) was higher in patients with upper GI bleeding. The threshold BUN value for distinguishing upper from lower GI bleeding was 21.0 mg/dL, with a specificity of 93.0%.
Publish Date	2015-05-30 13:32
Citation	Tomizawa M, Shinozaki F, Hasegawa R, Shirai Y, Motoyoshi Y, Sugiyama T, Yamamoto S, Ishige N. Laboratory test variables useful for distinguishing upper from lower gastrointestinal bleeding. World J Gastroenterol 2015; 21(20): 6246-6251
URL	http://www.wjgnet.com/1007-9327/full/v21/i20/6246.htm
DOI	http://dx.doi.org/10.3748/wjg.v21.i20.6246

Full Article (PDF)	WJG-21-6246.pdf
Full Article (Word)	WJG-21-6246.doc
Manuscript File	15017-Review.doc
Answering Reviewers	15017-Answering reviewers.pdf
Biostatistics Review Certificate	15017-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form	15017-Conflict-of-interest statement.pdf
Copyright License Agreement	15017-Copyright assignment.pdf
Institutional Review Board Approval Form or Document	15017-Institutional Review Board (IRB) statement.pdf
Non-Native Speakers of English Editing Certificate	Editing_Certificate_20141104092959.pdf
Peer-review Report	15017-Peer-review(s).pdf
Scientific Misconduct Check	15017-CorssCheck.jpg
Scientific Editor Work List	15017-Scientific editor work list.pdf