ISSN |
1007-9327 (print) and 2219-2840 (online) |
Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
Copyright |
© The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
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Article Reprints |
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Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
Website |
http://www.wjgnet.com |
Category |
Oncology |
Manuscript Type |
Randomized Clinical Trial |
Article Title |
Gastrointestinal perforation in metastatic colorectal cancer patients with peritoneal metastases receiving bevacizumab
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Manuscript Source |
Invited Manuscript |
All Author List |
Aflah Roohullah, Hui-Li Wong, Katrin M Sjoquist, Peter Gibbs, Kathryn Field, Ben Tran, Jeremy Shapiro, Joe Mckendrick, Desmond Yip, Louise Nott, Val Gebski, Weng Ng, Wei Chua, Timothy Price, Niall Tebbutt and Lorraine Chantrill |
Funding Agency and Grant Number |
Funding Agency |
Grant Number |
Cancer Australia and the Cancer Institute New South Wales for the AGITG MAX Trial |
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Corresponding Author |
Aflah Roohullah, MBChB, FRACP, Macarthur Cancer Therapy Centre, Campbelltown Hospital, Therry Road, Campbelltown NSW 2560, Australia. aflah.roohullah@sswahs.nsw.gov.au |
Key Words |
Peritoneal neoplasms; Colorectal neoplasms; Bevacizumab; Intestinal perforation; Capecitabine |
Core Tip |
This report is an analysis of three prospective studies including a randomized clinical trial. We analysed the rates of gastrointestinal perforation in patients with metastatic colorectal cancer and peritoneal disease receiving bevacizumab and systemic therapy. Previous reports had raised concerns regarding the risk of gastrointestinal perforation in this population. Our reports suggest that the absolute risk is not elevated and in addition clinicians appear to be confident in using bevacizumab in patients with colorectal cancer and peritoneal disease. We recommend that the presence of peritoneal disease is not a contraindication to the use of bevacizumab and systemic therapy. |
Publish Date |
2015-05-13 10:38 |
Citation |
Roohullah A, Wong HL, Sjoquist KM, Gibbs P, Field K, Tran B, Shapiro J, Mckendrick J, Yip D, Nott L, Gebski V, Ng W, Chua W, Price T, Tebbutt N, Chantrill L. Gastrointestinal perforation in metastatic colorectal cancer patients with peritoneal metastases receiving bevacizumab. World J Gastroenterol 2015; 21(17): 5352-5358 |
URL |
http://www.wjgnet.com/1007-9327/full/v21/i17/5352.htm |
DOI |
http://dx.doi.org/10.3748/wjg.v21.i17.5352 |