Publication Name	World Journal of Gastrointestinal Oncology
Manuscript ID	18570
Country	United States

Received	2015-04-24 09:10
Peer-Review Started	2015-04-24 19:25
To Make the First Decision	2015-06-25 17:53
Return for Revision	2015-07-01 09:44
Revised	2015-07-10 04:53
Second Decision	2015-09-06 19:51
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2015-09-16 19:00
Articles in Press	2015-09-16 19:00
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2015-10-10 20:10
Publish the Manuscript Online	2015-10-19 09:39

ISSN	1948-5204 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
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Website	http://www.wjgnet.com

Category	Medicine, Research & Experimental
Manuscript Type	Review
Article Title	Role of retinoids in the prevention and treatment of colorectal cancer
Manuscript Source	Invited Manuscript
All Author List	Catherine C Applegate and Michelle A Lane
Funding Agency and Grant Number
Corresponding Author	Michelle A Lane, PhD, Associate Professor, School of Family and Consumer Sciences, Nutrition and Foods Program, Texas State University, FCS Building, 601 University Drive, San Marcos, TX 78666, United States. ml48@txstate.edu
Key Words	Colorectal cancer; Retinoid; Vitamin A; β-catenin; Phosphatidylinositol-3-kinase; K-ras; Cyclooxy­genase-2; Peroxisome proliferator-activated receptor γ; P53; Phosphatase and tensin homolog deleted on chromosome 10
Core Tip	Vitamin A and its derivatives, the retinoids, have been widely studied in many types of cancer for their ability to increase cell differentiation and decrease cell proliferation. This review focuses on the ability of retinoids to affect signaling pathways commonly disrupted in colorectal cancer. We discuss vitamin A metabolism and signaling, how this process becomes aberrant as colorectal cancer progresses, and how treatment with both dietary vitamin A and exogenous retinoids can alter these dysregulated signaling pathways to decrease colorectal cancer cell proliferation and invasion.
Publish Date	2015-10-19 09:39
Citation	Applegate CC, Lane MA. Role of retinoids in the prevention and treatment of colorectal cancer. World J Gastrointest Oncol 2015; 7(10): 184-203
URL	http://www.wjgnet.com/1948-5204/full/v7/i10/184.htm
DOI	http://dx.doi.org/10.4251/wjgo.v7.i10.184

Full Article (PDF)	WJGO-7-184.pdf
Full Article (Word)	WJGO-7-184.doc
Manuscript File	18570-Review.docx
Answering Reviewers	18570-Answering reviewers.pdf
Audio Core Tip	18750-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	18570-Conflict-of-interest statement.pdf
Copyright License Agreement	18570-Copyright assignment.pdf
Peer-review Report	18570-Peer-review(s).pdf
Scientific Misconduct Check	18570-Scientific misconduct check.pdf
Scientific Editor Work List	18570-Scientific editor work list.pdf