Publication Name	World Journal of Clinical Cases
Manuscript ID	18624
Country

Received	2015-04-27 14:06
Peer-Review Started	2015-05-04 13:32
To Make the First Decision	2015-06-03 14:21
Return for Revision	2015-06-09 11:33
Revised	2015-06-20 22:29
Second Decision	2015-07-17 08:24
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2015-07-27 17:14
Articles in Press	2015-07-27 17:14
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2015-08-26 14:46
Publish the Manuscript Online	2015-09-15 18:41

ISSN	2307-8960 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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Category	Gastroenterology & Hepatology
Manuscript Type	Review
Article Title	Vitamin K and hepatocellular carcinoma: The basic and clinic
Manuscript Source	Invited Manuscript
All Author List	Xia Jinghe, Toshihiko Mizuta and Iwata Ozaki
Funding Agency and Grant Number
Corresponding Author	Iwata Ozaki, MD, PhD, Health Admi­nistration Center, Saga University, 5-1-1 Nabeshima, Saga 849-8501, Japan. ozaki@cc.saga-u.ac.jp
Key Words	Hepatocellular carcinoma; Vitamin K; Steroid and xenobiotic receptor; Nuclear factor-kappa B; Protein kinase A; Protein kinase C; Drug repositioning
Core Tip	Vitamin K (VK) is essential nutrient initially identified as a cofactor to produce functional coagulation factors. In addition to the roles in hemostasis, pleiotropic effects of VK in bone health, atherosclerotic diseases and cancer have been attracting. VK has been shown to play tumor-suppressive roles in several cancers including hepatocellular carcinoma (HCC) and reported to have beneficial effects in the treatment of HCC although its anti-tumor effects remain to be improved. Currently novel VK derivatives are under developing and will be applied to cancer treatment in the future.
Publish Date	2015-09-15 18:41
Citation	Jinghe X, Mizuta T, Ozaki I. Vitamin K and hepatocellular carcinoma: The basic and clinic. World J Clin Cases 2015; 3(9): 757-764
URL	http://www.wjgnet.com/2307-8960/full/v3/i9/757.htm
DOI	http://dx.doi.org/10.12998/wjcc.v3.i9.757

Full Article (PDF)	WJCC-3-757.pdf
Full Article (Word)	WJCC-3-757.doc
Manuscript File	18624-Review.docx
Answering Reviewers	18624-Answering reviewers.pdf
Audio Core Tip	18624-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	18624-Conflict-of-interest statement.pdf
Copyright License Agreement	18624-Copyright assignment.pdf
Peer-review Report	18624-Peer-review(s).pdf
Scientific Misconduct Check	18624-Scientific misconduct check.pdf
Scientific Editor Work List	18624-Scientific editor work list.pdf