Publication Name	World Journal of Hepatology
Manuscript ID	2230
Country	Singapore

Received	2013-02-07 20:52
Peer-Review Started	2013-02-10 21:05
To Make the First Decision	2013-03-04 10:40
Return for Revision	2013-03-04 11:47
Revised
Second Decision	2013-05-07 17:39
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2013-05-08 09:14
Articles in Press
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2013-05-17 16:38
Publish the Manuscript Online	2013-05-27 12:24

ISSN	1948-5182 (online)
Open Access
Copyright
Article Reprints	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Autobiography
Article Title	Prevalence and risk factors of methotrexate hepatoxicity in Asian patients with psoriasis
Manuscript Source	Invited Manuscript
All Author List	Chong Meng Yeo, Vui Heng Chong, Arul Earnest and Wei Lyn Yang
Funding Agency and Grant Number
Corresponding Author	Dr. Chong Meng Yeo, Department of Gastroenterology, Tan Tock Seng Hospital, 11 Jalan Tan Tock Seng, Singapore 308433, Singapore. chong_meng_yeo@ttsh.com.sg
Key Words	Hepatotoxicity; Liver fibrosis; Methotrexate; Risk factors; Cirrhosis
Core Tip	Old studies have shown that the prevalence of methotrexate (MTX) associated liver fibrosis and cirrhosis to be as high as 50% and 26% respectively. Later studies have shown that the risk is much lower than previously reported. These studies have been based on western patients. To date, there is no study that had assessed MTX hepatotoxicity in Asian patient based on liver histology. This study showed that the risk of methotrexate hepatoxicity in Asian patients with psoriasis is also low and progression is minimal. We showed that ethnicity and presence of diabetes and hyperlipidemia, part of the metabolic syndrome may be important factors.
Publish Date	2013-05-27 12:24
Citation	Yeo CM, Chong VH, Earnest A, Yang WL. Prevalence and risk factors of methotrexate hepatoxicity in Asian patients with psoriasis. World J Hepatol 2013; 5(5): 275-280
URL	http://www.wjgnet.com/1948-5182/full/v5/i5/275.htm
DOI	http://dx.doi.org/10.4254/wjh.v5.i5.275

Full Article (PDF)	WJH-5-275.pdf
Manuscript File	2230-Review.doc
Answering Reviewers	2230-Answering reviewers.pdf
Copyright License Agreement	2230-Copyright assignment.pdf
Peer-review Report	2230-Peer review(s).pdf
Scientific Editor Work List	2230-Scientific editor work list.doc