ISSN |
1007-9327 (print) and 2219-2840 (online) |
Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
Copyright |
© The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved. |
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Permissions |
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Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
Website |
http://www.wjgnet.com |
Category |
Gastroenterology & Hepatology |
Manuscript Type |
Basic Study |
Article Title |
Effect of artesunate supplementation on bacterial translocation and dysbiosis of gut microbiota in rats with liver cirrhosis
|
Manuscript Source |
Unsolicited Manuscript |
All Author List |
Yun-Xia Chen, Li-Na Lai, Hui-Ying Zhang, Yang-Hui Bi, Li Meng, Xu-Jiong Li, Xiao-Xia Tian, Li-Min Wang, Yi-Min Fan, Zhong-Fu Zhao, De-Wu Han and Cheng Ji |
Funding Agency and Grant Number |
Funding Agency |
Grant Number |
National Natural Science Foundation of China |
81070339 |
International Science and Technology Cooperation Project of Shanxi |
2010081068 |
Key Laboratory Foundation of Cellular Physiology Department of Shanxi Medical School and Provincial Ministry of Education |
2010-09 |
Fund for Returned Students of Shanxi |
211-091 |
Fund for Returned Medical Doctors of Changzhi Medical College |
2010-01 |
Science and Technology Innovation Team Project of Changzhi Medical College |
CX201409 |
College Student Innovation and Entrepreneurship Training Project of Shanxi Province |
2014308 |
US NIH |
R21AA023952(to Cheng Ji) |
US NIH |
P30DK48522-21 |
|
Corresponding Author |
Hui-Ying Zhang, MD, Professor, Department of Pathophysiology, Changzhi Medical College, 161 Jiefang Dongjie, Changzhi 046000, Shanxi Province, China. zhanghy2001@163.com |
Key Words |
Hepatic cirrhosis; Gut microbiota; Bacterial translocation; Artesunate; Intervention |
Core Tip |
Artesunate (AS) is antimalarial yet potentially anti-inflammatory. We evaluated the effect of AS supplementation on bacterial translocation (BT) and the gut microbiota in a rat model of liver cirrhosis. Dysbiosis of gut microbiota, injury of intestinal mucosal barrier and BT occurred as liver cirrhosis progressed, which might enhance inflammation and aggravate liver injury. AS may have other non-antimalaria effects that modulate gut microbiota, inhibit BT and alleviate inflammation, leading to a reduction in carbon tetrachloride, alcohol and high fat-caused damages to the liver and intestine. |
Publish Date |
2016-03-04 19:53 |
Citation |
Chen YX, Lai LN, Zhang HY, Bi YH, Meng L, Li XJ, Tian XX, Wang LM, Fan YM, Zhao ZF, Han DW, Ji C. Effect of artesunate supplementation on bacterial translocation and dysbiosis of gut microbiota in rats with liver cirrhosis. World J Gastroenterol 2016; 22(10): 2949-2959 |
URL |
http://www.wjgnet.com/1007-9327/full/v22/i10/2949.htm |
DOI |
http://dx.doi.org/10.3748/wjg.v22.i10.2949 |