Publication Name	World Journal of Hepatology
Manuscript ID	25172
Country	Brazil

Received	2016-02-26 08:33
Peer-Review Started	2016-02-26 17:05
To Make the First Decision	2016-03-23 17:34
Return for Revision	2016-03-25 19:58
Revised	2016-05-03 03:39
Second Decision	2016-05-09 08:48
Accepted by Journal Editor-in-Chief	2016-05-09 16:13
Accepted by Company Editor-in-Chief	2016-05-27 10:21
Articles in Press	2016-05-27 10:21
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2016-05-31 10:08
Publish the Manuscript Online	2016-06-14 15:22

ISSN	1948-5182 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
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Category	Gastroenterology & Hepatology
Manuscript Type	Prospective Study
Article Title	Circulating insulin-like growth factor-binding protein 3 as prognostic biomarker in liver cirrhosis
Manuscript Source	Invited Manuscript
All Author List	Carina Gabriela Correa, Bruno da Silveira Colombo, Marcelo Fernando Ronsoni, Pedro Eduardo Soares e Silva, Leonardo Fayad, Telma Erotides Silva, Letícia Muraro Wildner, Maria Luiza Bazzo, Esther Buzaglo Dantas-Correa, Janaína Luz Narciso-Schiavon and Leonardo de Lucca Schiavon
Funding Agency and Grant Number
Corresponding Author	Dr. Leonardo de Lucca Schiavon, Divi­sion of Gastroenterology, Federal University of Santa Catarina, Rua Deputado Antonio Edu Vieira 1310, casa 217, Bairro Pantanal, Florianópolis, Santa Catarina 88.040-001, Brazil. leo-jf@uol.com.br
Key Words	Liver cirrhosis; Acute decompensation; Insulin-like growth factor binding protein 3; Acute-on-chronic liver failure; Prognosis
Core Tip	Insulin-like growth factor-binding protein 3 (IGFBP-3) levels are decreased in cirrhosis and seem to correlate with the intensity of hepatic dysfunction, but its prognostic significance is uncertain. In this prospective cohort study, IGFBP-3 levels correlated with variables associated with the intensity of liver dysfunction in both outpatients with stable cirrhosis and in subjects hospitalized for acute decompensation. IGFBP-3 levels increased significantly after discharge and after liver transplantation. Lower IGFBP-3 levels were associated with poor outcomes in both outpatients with stable cirrhosis and in those hospitalized for acute decompensation, suggesting that it can be used in clinical practice as a prognostic biomarker in cirrhosis.
Publish Date	2016-06-14 15:22
Citation	Correa CG, Colombo BS, Ronsoni MF, Soares e Silva PE, Fayad L, Silva TE, Wildner LM, Bazzo ML, Dantas-Correa EB, Narciso-Schiavon JL, Schiavon LL. Circulating insulin-like growth factor-binding protein 3 as prognostic biomarker in liver cirrhosis. World J Hepatol 2016; 8(17): 739-748
URL	http://www.wjgnet.com/1948-5182/full/v8/i17/739.htm
DOI	http://dx.doi.org/10.4254/wjh.v8.i17.739

Full Article (PDF)	WJH-8-739.pdf
Full Article (Word)	WJH-8-739.doc
Manuscript File	25172-Review.doc
Answering Reviewers	25172-Answering reviewers.pdf
Audio Core Tip	25172-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	25172-Conflict-of-interest statement.pdf
Copyright License Agreement	25172-Copyright assignment.pdf
Institutional Review Board Approval Form or Document	25172-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate	25172-Language certificate.pdf
Peer-review Report	25172-Peer-review(s).pdf
Journal Editor-in-Chief Review Report	25172-Journal editor-in-chief review report.pdf
Scientific Misconduct Check	25172-Scientific misconduct check.pdf
Scientific Editor Work List	25172-Scientific editor work list.pdf