Publication Name	World Journal of Gastroenterology
Manuscript ID	25570
Country	China

Received	2016-03-15 09:53
Peer-Review Started	2016-03-16 19:20
To Make the First Decision	2016-03-31 09:52
Return for Revision	2016-04-01 12:15
Revised	2016-04-17 16:24
Second Decision	2016-04-22 10:31
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2016-05-04 18:41
Articles in Press	2016-05-04 18:41
Publication Fee Transferred
Edit the Manuscript by Language Editor	2016-07-05 17:30
Typeset the Manuscript	2016-07-26 09:18
Publish the Manuscript Online	2016-07-29 20:32

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
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Website	http://www.wjgnet.com

Category	Oncology
Manuscript Type	Topic Highlights
Article Title	Metastasis-associated in colon cancer-1 in gastric cancer: beyond metastasis
Manuscript Source	Invited Manuscript
All Author List	Zhen-zhen Wu, Li-shan Chen, Rui Zhou, Jian-ping Bin, Yu-lin Liao and Wang-jun Liao
Funding Agency and Grant Number
Corresponding Author	Wang-jun Liao, MD, PhD, Department of Oncology, Nanfang Hospital, Southern Medical University, No. 1838 Guangzhou Avenue North, Guangzhou 510515, Guangdong province, China. nfyyliaowj@163.com
Key Words	Metastasis-associated in colon cancer-1; Gastric cancer; Epithelial-to-mesenchymal transition; Vasculogenic mimicry; Lymphangiogenesis; Warburg effect; Tumor microenvironment
Core Tip	Metastasis-associated in colon cancer-1 (MACC1) is an oncogene that is involved in multiple aspects of gastric cancer (GC). Although MACC1 was first identified as a promoter of the epithelial-mesenchymal transition in GC, as in colon cancer, it has subsequently been found to have functions in GC far beyond metastasis, including vasculogenic mimicry, lymphangiogenesis and metabolic reprogramming. These features of tumorigenesis and tumor progression involve both GC cells and the surrounding tumor microenvironment, indicating that the tumor-promoting functions of MACC1 may hinge on its ability to mediate the tumor microenvironment.
Publish Date	2016-07-29 20:32
Citation	Wu Zz, Chen Ls, Zhou R, Bin Jp, Liao Yl, Liao Wj. Metastasis-associated in colon cancer-1 in gastric cancer: beyond metastasis. World J Gastroenterol 2016; 22(29): 6629-6637
URL	http://www.wjgnet.com/1007-9327/full/v22/i29/6629.htm
DOI	http://dx.doi.org/10.3748/wjg.v22.i29.6629

Full Article (PDF)	WJG-22-6629.pdf
Full Article (Word)	WJG-22-6629.doc
Manuscript File	25570-Review.docx
Answering Reviewers	25570-Answering reviewers.pdf
Audio Core Tip	25570-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	25570-Conflict-of-interest statement.pdf
Copyright License Agreement	25570-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate	25570-Language certificate.pdf
Peer-review Report	25570-Peer-review(s).pdf
Scientific Misconduct Check	25570-Scientific misconduct check.pdf
Scientific Editor Work List	25570-Scientific editor work list.pdf