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Articles Published Processes
10/31/2016 9:01:00 AM | Browse: 1007 | Download: 1346
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Received |
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2016-05-01 17:34 |
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Peer-Review Started |
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2016-05-02 10:31 |
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To Make the First Decision |
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2016-07-04 16:49 |
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Return for Revision |
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2016-07-05 10:53 |
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Revised |
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2016-07-14 20:50 |
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Second Decision |
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2016-08-08 15:18 |
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Accepted by Journal Editor-in-Chief |
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2016-08-09 06:04 |
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Accepted by Company Editor-in-Chief |
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2016-08-16 13:53 |
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Articles in Press |
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2016-08-16 13:55 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2016-10-24 14:29 |
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Publish the Manuscript Online |
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2016-10-31 09:01 |
| ISSN |
2150-5349 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Basic Study |
| Article Title |
A20 inhibits lipopolysaccharide-induced inflammation in enterocytes
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Cui-Fang Zheng, Jie-Ru Shi, Ying Huang and Sheng-Nan Wang |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Natural Science Foundation of China |
81300291 |
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| Corresponding Author |
Ying Huang, MD, PhD, Department of Gastroenterology, Children’s Hospital of Fudan University, No. 399 Wan-Yuan Road, Minhang District, Shanghai 201102, China. yhuang815@163.com |
| Key Words |
A20 (TNFAIP3); Lipopolysaccharide; Nuclear factor-κB; Inflammatory bowel disease |
| Core Tip |
The use of A20-deficient mice and RNA interference technologies has revealed that mice or enterocytes lacking A20 showed hyper-responsiveness to stimulation. However, studies on whether the overexpression of A20 can extenuate enterocyte inflammation are limited. Our present results demonstrated that the expression of A20 was increased in a dose- and time-dependent manner upon lipopolysaccharide (LPS) stimulation in intestinal epithelial cells. More importantly, the overexpression of A20 suppressed the activation of nuclear factor-κB and the induction of pro-inflammatory molecules, such as Tumor necrosis factor-a and IL-8. Taken together, these findings indicate that A20 plays a critical role in limiting LPS-induced inflammation in the gut luminal and may be a potential therapeutic tool for immune and inflammatory diseases. |
| Publish Date |
2016-10-31 09:01 |
| Citation |
Zheng CF, Shi JR, Huang Y, Wang SN. A20 inhibits lipopolysaccharide-induced inflammation in enterocytes. World J Gastrointest Pharmacol Ther 2016; 7(4): 540-549 |
| URL |
http://www.wjgnet.com/2150-5349/full/v7/i4/540.htm |
| DOI |
http://dx.doi.org/10.4292/wjgpt.v7.i4.540 |
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