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11/12/2016 1:33:00 PM | Browse: 1047 | Download: 2066
Publication Name World Journal of Gastroenterology
Manuscript ID 28819
Country South Korea
Received
2016-07-18 10:07
Peer-Review Started
2016-07-18 21:40
To Make the First Decision
2016-08-29 08:43
Return for Revision
2016-09-02 10:05
Revised
2016-09-10 21:09
Second Decision
2016-09-30 13:03
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2016-10-10 17:32
Articles in Press
2016-10-10 17:32
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2016-11-09 15:23
Publish the Manuscript Online
2016-11-12 13:34
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Gastroenterology & Hepatology
Manuscript Type Retrospective Study
Article Title Lymphovascular invasion in more than one-quarter of small rectal neuroendocrine tumors
Manuscript Source Unsolicited Manuscript
All Author List Mi Jung Kwon, Ho Suk Kang, Jae Seung Soh, Hyun Lim, Jong Hyeok Kim, Choong Kee Park, Hye-Rim Park and Eun Sook Nam
Funding Agency and Grant Number
Corresponding Author Ho Suk Kang, MD, Department of Internal Medicine, Hallym University Sacred Heart Hospital, 22, Gwanpyeong-ro 170 beon-gil, Dongan-gu, Anyang-si 431-796, South Korea. hskang76@hallym.or.kr
Key Words Rectum; Neuroendocrine tumor; Lymphatic; Immunohistochemistry; Prognosis
Core Tip The majority of rectal neuroendocrine tumors (NETs) are small (66%-80% are ≤ 1 cm in diameter) and endoscopic resection techniques have shown successful outcomes. However, lymphovascular inva?sions, a well-established risk factor for lymph node metastasis, are often found at endoscopically resected specimens and there are no definite guidelines about these cases. Therefore, we investigate the frequency and prognostic significance of lymphovascular invasion (LVI) in small endoscopically resected rectal NETs. We found that LVI may be present in a high percentage of small rectal NETs by two histologic methods; hematoxylin and eosin staining and ancillary immunohistochemical staining (D2-40 and Elastica van Gieson). On the other hands, LVI was not associated with lymph node metastasis or recurrence in small rectal NETs (≤ 1 cm) during a 3 year-follow up period. Although our follow-up period was short, but I'm confident in our studies will be the cornerstone of future researches about significance of LVI in small rectal NETs.
Publish Date 2016-11-12 13:34
Citation Kwon MJ, Kang HS, Soh JS, Lim H, Kim JH, Park CK, Park HR, Nam ES. Lymphovascular invasion in more than one-quarter of small rectal neuroendocrine tumors. World J Gastroenterol 2016; 22(42): 9400-9410
URL http://www.wjgnet.com/1007-9327/full/v22/i42/9400.htm
DOI http://dx.doi.org/10.3748/wjg.v22.i42.9400
Full Article (PDF) WJG-22-9400.pdf
Full Article (Word) WJG-22-9400.doc
Manuscript File 28819-Review.docx
Answering Reviewers 28819-Answering reviewers.pdf
Audio Core Tip 28819-Audio core tip.wmv
Conflict-of-Interest Disclosure Form 28819-Conflict-of-interest statement.pdf
Copyright License Agreement 28819-Copyright assignment.pdf
Institutional Review Board Approval Form or Document 28819-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate 28819-Language certificate.pdf
Peer-review Report 28819-Peer-review(s).pdf
Scientific Misconduct Check 28819-Scientific misconduct check.pdf
Scientific Editor Work List 28819-Scientific editor work list.pdf