Publication Name	World Journal of Gastroenterology
Manuscript ID	29807
Country	Spain

Received	2016-08-28 16:47
Peer-Review Started	2016-08-31 19:58
To Make the First Decision	2016-09-20 08:34
Return for Revision	2016-09-22 19:05
Revised	2016-09-28 22:45
Second Decision	2016-11-07 09:25
Accepted by Journal Editor-in-Chief	2016-11-07 21:01
Accepted by Company Editor-in-Chief	2016-11-13 15:26
Articles in Press	2016-11-13 15:26
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2016-11-25 16:46
Publish the Manuscript Online	2016-12-26 19:13

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
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Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Editorial
Article Title	Protons pump inhibitor treatment and lower gastrointestinal bleeding: Balancing risks and benefits
Manuscript Source	Invited Manuscript
All Author List	Alberto Lué and Angel Lanas
Funding Agency and Grant Number
Corresponding Author	Angel Lanas, MD, DSc, Professor, Chairman, Digestive Diseases Service, University Clinic Hospital Lozano Blesa, Avenida San Juan Bosco, 50009 Zaragoza, Spain. alanas@unizar.es
Key Words	Proton pump inhibitor; Small bowel; Small bowel; Lower gastrointestinal bleeding; Nonsteroidal anti-inflammatory drugs
Core Tip	Proton pump inhibitors (PPIs) reduce the risk of upper, but not lower gastrointestinal bleeding (LGB) in patients receiving nonsteroidal anti-inflammatory drugs (NSAIDs) or low-dose aspirin. PPIs could exacerbate small bowel damage related to NSAIDs and low-dose aspirin, which contributes to an increased risk of LGB possibly related to pathological modifications of small bowel microbiota. LGB is a life-threatening condition, especially in older patients with comorbidities treated with NSAIDs, aspirin, or anticoagulants. No accepted treatments exist for decreasing the risk of LGB in these patients. Future research is needed on reducing inappropriate PPI use and evaluating possible pharmacologic interventions to decrease the risk of gastrointestinal bleeding.
Publish Date	2016-12-26 19:13
Citation	Lué A, Lanas A. Protons pump inhibitor treatment and lower gastrointestinal bleeding: Balancing risks and benefits. World J Gastroenterol 2016; 22(48): 10477-10481
URL	http://www.wjgnet.com/1007-9327/full/v22/i48/10477.htm
DOI	http://dx.doi.org/10.3748/wjg.v22.i48.10477

Full Article (PDF)	WJG-22-10477.pdf
Full Article (Word)	WJG-22-10477.doc
Manuscript File	29807-Review.docx
Answering Reviewers	29807-Answering reviewers.pdf
Audio Core Tip	29807-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	29807-Conflict-of-interest statement.PDF
Copyright License Agreement	29807-Copyright assignment.PDF
Non-Native Speakers of English Editing Certificate	29807-Language certificate.pdf
Peer-review Report	29807-Peer-review(s).pdf
Journal Editor-in-Chief Review Report	29807-Journal editor-in-chief review report.pdf
Scientific Misconduct Check	29807-Scientific misconduct check.pdf
Scientific Editor Work List	29807-Scientific editor work list.pdf