Publication Name	World Journal of Gastroenterology
Manuscript ID	29814
Country	Spain

Received	2016-08-28 17:02
Peer-Review Started	2016-08-31 20:25
To Make the First Decision	2016-10-20 13:00
Return for Revision	2016-10-21 10:54
Revised	2016-11-02 06:05
Second Decision	2016-11-11 14:37
Accepted by Journal Editor-in-Chief	2016-11-11 17:37
Accepted by Company Editor-in-Chief	2016-11-16 16:32
Articles in Press	2016-11-16 16:32
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2016-12-02 22:12
Publish the Manuscript Online	2017-01-14 10:27

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved.
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Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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Website	http://www.wjgnet.com

Category	Surgery
Manuscript Type	Editorial
Article Title	Second-look surgery plus hyperthermic intraperitoneal chemotherapy for patients with colorectal cancer at high risk of peritoneal carcinomatosis: Does it really save lives?
Manuscript Source	Invited Manuscript
All Author List	Delia Cortes-Guiral, Dominique Elias, Pedro Antonio Cascales-Campos, Alfredo Badía Yébenes, Ismael Guijo Castellano, Ana Isabel León Carbonero, José Ignacio Martín Valadés, Jesus Garcia-Foncillas and Damian Garcia-Olmo
Funding Agency and Grant Number
Corresponding Author	Delia Cortes-Guiral, MD, Department of General Surgery (Peritoneal Surface Surgical Oncology), Fundación Jiménez Díaz Hospital, Avda. Reyes Católicos 2, 28050 Madrid, Spain. delia.cortes.guiral@gmail.com
Key Words	Second-look surgery; High-risk patients; Peritoneal carcinomatosis; Hyperthermic intraperitoneal chemotherapy; Colo-rectal cancer
Core Tip	Metachronous peritoneal carcinomatosis of colorectal origin is so predictable that at-risk patients can be clearly identified. Treating peritoneal carcinomatosis in its early stages, when the peritoneal carcinomatosis index is as low as possible, is vitally important to get the maximum benefit from cytoreductive surgery plus hyperthermic intraperitoneal chemotherapy (HIPEC). Second-look surgery with HIPEC or prophylactic HIPEC at the time of the first intervention have been proposed as means of preventing and/or anticipating clinical or radiological relapse in at-risk patients. Both techniques have shown a significant decrease in peritoneal relapses and should be considered essential weapons in the management of colorectal cancer.
Publish Date	2017-01-14 10:27
Citation	Cortes-Guiral D, Elias D, Cascales-Campos PA, Badía Yébenes A, Guijo Castellano I, León Carbonero AI, Martín Valadés JI, Garcia-Foncillas J, Garcia-Olmo D. Second-look surgery plus hyperthermic intraperitoneal chemotherapy for patients with colorectal cancer at high risk of peritoneal carcinomatosis: Does it really save lives? World J Gastroenterol 2017; 23(3): 377-381
URL	http://www.wjgnet.com/1007-9327/full/v23/i3/377.htm
DOI	http://dx.doi.org/10.3748/wjg.v23.i3.377

Full Article (PDF)	WJG-23-377.pdf
Full Article (Word)	WJG-23-377.doc
Manuscript File	29814-Review.docx
Answering Reviewers	29814-Answering reviewers.pdf
Audio Core Tip	29814-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	29814-Conflict-of-interest statement.pdf
Copyright License Agreement	29814-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate	29814-Language certificate.pdf
Peer-review Report	29814-Peer-review(s).pdf
Journal Editor-in-Chief Review Report	29814-Journal editor-in-chief review report.pdf
Scientific Misconduct Check	29814-Scientific misconduct check.pdf
Scientific Editor Work List	29814-Scientific editor work list.pdf