| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Case Control Study |
| Article Title |
Polymorphisms of microRNA target genes IL12B, INSR, CCND1 and IL10 in gastric cancer
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Vytenis Petkevicius, Violeta Salteniene, Simonas Juzenas, Thomas Wex, Alexander Link, Marcis Leja, Ruta Steponaitiene, Jurgita Skieceviciene, Limas Kupcinskas, Laimas Jonaitis, Gediminas Kiudelis, Peter Malfertheiner and Juozas Kupcinskas |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Lithuanian Research Council Grant |
MIP-14418 |
|
| Corresponding Author |
Juozas Kupcinskas, MD, PhD, Gastroenterologist, Chief Researcher, Department of Gastroenterology, Lithuanian University of Health Sciences, Eiveniu str. 2, Kaunas 50009, Lithuania. juozas.kupcinskas@lsmuni.lt |
| Key Words |
Gastric cancer; miRNA; Target genes; Single-nucleotide polymorphisms |
| Core Tip |
Several studies have evaluated an association between single-nucleotide polymorphisms (SNPs) and gastric cancer (GC) risk. Here we used novel approach. Using bioinformatical analysis tools, several SNPs were identified as potential target sites of microRNAs that previously have been linked with gastric carcinogenesis. This study evaluated an association between SNPs in the INSR (rs1051690), IL12B (rs1368439), CCND1 (rs7177), and IL10 (rs3024498) genes and risk of GC in subjects of European descent. The study found that INSR rs1051690 SNP was associated with increased risk of GC, while polymorphisms in IL12B, CCND1 and IL10 genes showed no association with GC. |
| Publish Date |
2017-05-20 12:26 |
| Citation |
Petkevicius V, Salteniene V, Juzenas S, Wex T, Link A, Leja M, Steponaitiene R, Skieceviciene J, Kupcinskas L, Jonaitis L, Kiudelis G, Malfertheiner P, Kupcinskas J. Polymorphisms of microRNA target genes IL12B, INSR, CCND1 and IL10 in gastric cancer. World J Gastroenterol 2017; 23(19): 3480-3487 |
| URL |
http://www.wjgnet.com/1007-9327/full/v23/i19/3480.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v23.i19.3480 |
