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4/28/2017 10:26:16 AM | Browse: 1216 | Download: 1853
Publication Name World Journal of Gastroenterology
Manuscript ID 32073
Country/Territory Canada
Received
2016-12-24 16:42
Peer-Review Started
2016-12-28 16:05
To Make the First Decision
2017-01-19 13:54
Return for Revision
2017-01-20 16:36
Revised
2017-02-14 03:40
Second Decision
2017-03-24 12:21
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2017-03-31 07:51
Articles in Press
2017-03-31 07:51
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2017-04-12 20:11
Publish the Manuscript Online
2017-04-28 10:26
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Gastroenterology & Hepatology
Manuscript Type Basic Study
Article Title Droplet digital PCR for quantification of ITGA6 in a stool mRNA assay for the detection of colorectal cancers
Manuscript Source Invited Manuscript
All Author List Elizabeth Herring, Shigeru Kanaoka, Éric Tremblay and Jean-François Beaulieu
Funding Agency and Grant Number
Funding Agency Grant Number
Canadian Institutes of Health Research PPP133373
Corresponding Author Jean-François Beaulieu, PhD, Professor, Laboratory of Intestinal Physiopathology, Department of Anatomy and Cell Biology, Faculty of Medicine and Health Sciences, Université de Sherbrooke, Sherbrooke, Québec J1H5N4, Canada. jean-francois.beaulieu@usherbrooke.ca
Key Words Colorectal cancer; Advanced adenoma; Non-invasive screening; Biomarker; mRNA
Core Tip We investigated the use of droplet digital polymerase chain reaction (ddPCR) for detecting host mRNA markers in stools as a non-invasive test for colorectal cancer screening using ITGA6 and ITGA6A as established medium and low abundance stool biomarkers. Our side by side comparison of ddPCR and qPCR on stool samples obtained from patients with advanced adenomas and colorectal cancers and controls using duplex TaqMan reactions revealed that both methods performed equally well.
Publish Date 2017-04-28 10:26
Citation Herring E, Kanaoka S, Tremblay E, Beaulieu JF. Droplet digital PCR for quantification of ITGA6 in a stool mRNA assay for the detection of colorectal cancers. World J Gastroenterol 2017; 23(16): 2891-2898
URL http://www.wjgnet.com/1007-9327/full/v23/i16/2891.htm
DOI http://dx.doi.org/10.3748/wjg.v23.i16.2891
Full Article (PDF) WJG-23-2891.pdf
Full Article (Word) WJG-23-2891.doc
Manuscript File 32073-Review.doc
Answering Reviewers 32073-Answering reviewers.pdf
Audio Core Tip 32073-Audio core tip.mp3
Biostatistics Review Certificate 32073-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form 32073-Conflict-of-interest statement.pdf
Copyright License Agreement 32073-Copyright assignment.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s) 32073-Grant application form(s).pdf
Institutional Review Board Approval Form or Document 32073-Institutional review board statement.pdf
Peer-review Report 32073-Peer-review(s).pdf
Scientific Misconduct Check 32073-Scientific misconduct check.pdf
Scientific Editor Work List 32073-Scientific editor work list.pdf