| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2018. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Case Report |
| Article Title |
FANCA D1359Y mutation in a patient with gastric polyposis and cancer susceptibility: A case report and review of literature
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Jeffrey Peng Huang, Johnson Lin, Chi-Yuan Tzen, Wen-Yu Huang, Chia-Chi Tsai, Chih-Jen Chen, Yen-Jung Lu, Kuei-Fang Chou and Ying-Wen Su |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Mackay Memorial Hospital |
MMH-106-62 |
|
| Corresponding Author |
Ying-Wen Su, MD, PhD, Doctor, Staff Physician, Division of Hematology and Medical Oncology, Department of Internal Medicine, Mackay Memorial Hospital, No. 92, Section 2, Zhongshan North Road, Taipei 10491, Taiwan. yingwensu@gmail.com |
| Key Words |
Gastric polyposis; Gastric cancer; Adenocarcinoma; Fanconi’s anemia; Malignant transformation |
| Core Tip |
The genetic events that predispose benign polyps to carcinoma are rarely explored in gastric cancer. We studied a rare case that progressed from benign gastric polyposis to gastric cancer and disclosed a monoallelic germline mutation (D1359Y) at Fanconi’s anemia gene, which may contribute to the phenotype. Comparing the genetic events between benign and malignant gastric polyps, several recurrent mutations in DNA methylation (TET1, V873I), the β-catenin pathway (CTNNB1, S45F) and RHO signaling pathway (PLEKHG5, R203C) were identified. |
| Publish Date |
2018-10-12 05:32 |
| Citation |
Huang JP, Lin J, Tzen CY, Huang WY, Tsai CC, Chen CJ, Lu YJ, Chou KF, Su YW. FANCA D1359Y mutation in a patient with gastric polyposis and cancer susceptibility: A case report and review of literature. World J Gastroenterol 2018; 24(38): 4412-4418 |
| URL |
http://www.wjgnet.com/1007-9327/full/v24/i38/4412.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v24.i38.4412 |
