Publication Name	World Journal of Gastroenterology
Manuscript ID	4104
Country	Türkiye

Received	2013-06-14 09:26
Peer-Review Started	2013-06-14 16:43
To Make the First Decision	2013-07-05 18:26
Return for Revision	2013-07-14 20:41
Revised	2013-08-07 02:20
Second Decision	2013-08-20 10:28
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2013-08-20 12:46
Articles in Press
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2013-09-23 20:45
Publish the Manuscript Online	2013-10-18 17:02

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
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Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Autobiography
Article Title	Nilotinib-mediated mucosal healing in a rat model of colitis
Manuscript Source	Invited Manuscript
All Author List	Pinar Ataca, Mujde Soyturk, Meral Karaman, Mehtat Unlu, Ozgul Sagol, Gozde Dervis Hakim and Osman Yilmaz
Funding Agency and Grant Number	Funding Agency Grant Number Dokuz Eylul University Research Committee 42/2010
Corresponding Author	Dr. Pinar Ataca, Specialist, Department of Internal Medicine, Dokuz Eylul University School of Medicine, Kültür Mh., Cumhuriyet Blv 144, Inciralti, Izmir 35340, Turkey. pinar@ataca.tk
Key Words	Inflammatory bowel disease; Platelet-derived growth factor receptor; Tumor necrosis factor alpha; Tyrosine kinase inhibitor; Mucosal healing
Core Tip	Unresponsiveness to medical treatment in refractory inflammatory bowel disease (IBD) still poses a therapeutic challenge. To detect an alternative treatment option, we selected nilotinib based on the fact that tyrosine kinases inhibitors affect several key components in the pathogenesis of IBD, including tumor necrosis factor (TNF) alpha, platelet-derived growth factor receptor (PDGFR), and apoptosis. In a trinitrobenzene sulfonic acid-induced colitis rat model, we concluded that nilotinib has a significant effect on weight loss and on macroscopic and microscopic pathological scores, leading to significant mucosal healing. Although nilotinib caused a decrease in the PDGFR alpha and PDGFR beta levels, it did not have a significant effect on the apoptotic scores or TNF alpha levels.
Publish Date	2013-10-18 17:02
Citation	Ataca P, Soyturk M, Karaman M, Unlu M, Sagol O, Hakim Dervis G, Yilmaz O. Nilotinib-mediated mucosal healing in a rat model of colitis. World J Gastroenterol 2013; 19(37): 6237-6244
URL	http://www.wjgnet.com/1007-9327/full/v19/i37/6237.htm
DOI	http://dx.doi.org/10.3748/wjg.v19.i37.6237

Full Article (PDF)	WJG-19-6237.pdf
Manuscript File	4104-Review.docx
Answering Reviewers	4104-Answering reviewers.pdf
Copyright License Agreement	4104-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate	4104-Language certificate.pdf
Peer-review Report	4104-Peer reviews.pdf
Scientific Editor Work List	4104-Scientific editor work list.doc