| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Autobiography |
| Article Title |
Intestinal stem cell marker LGR5 expression during gastric carcinogenesis
|
| Manuscript Source |
Invited Manuscript |
| All Author List |
Zhi-Xue Zheng, Yu Sun, Zhao-De Bu, Lian-Hai Zhang, Zi-Yu Li, Ai-Wen Wu, Xiao-Jiang Wu, Xiao-Hong Wang, Xiao-Jing Cheng, Xiao-Fang Xing, Hong Du and Jia-Fu Ji |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Beijing Municipal Science and Technology Commission’s NOVA Program |
2009BG-02 |
| Beijing Municipal Health System Special funds of High-Level Medical Personnel Construction |
2013-3-082 |
|
| Corresponding Author |
Dr. Jia-Fu Ji, MD, FACS, Department of Gastrointestinal Surgery, Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Peking University Cancer Hospital and Institute, Fu Cheng Road 52, Hai Dian District, Beijing 100142, China. jiafuj@gmail.com
|
| Key Words |
Leucine-rich repeat-containing G protein-coupled receptor 5; Cancer stem cell; Gastric cancer; Intestinal metaplasia; Tumorigenesis |
| Core Tip |
This is the first study to evaluate the expression of leucine-rich repeat-containing G protein-coupled receptor 5 (LGR5), a putative cancer stem cell marker, in progressive stages of gastric carcinogenesis. The observation of increasing LGR5 expression in human gastric cancer lesions, following the loss of differentiation (from dysplastic to gastric cancer cases) and risk of spread (metastatic cases), suggests that this receptor may represent an important biomarker for early detection of patients at higher risk for gastric tumorigenesis. The observed distinctive expression pattern of LGR5 in intestinal metaplasia suggests that these cells may represent a precancerous condition but not carcinoma precursors. |
| Publish Date |
2013-12-18 10:00 |
| Citation |
Zheng ZX, Sun Y, Bu ZD, Zhang LH, Li ZY, Wu AW, Wu XJ, Wang XH, Cheng XJ, Xing XF, Du H, Ji JF. Intestinal stem cell marker LGR5 expression during gastric carcinogenesis. World J Gastroenterol 2013; 19(46): 8714-8721 |
| URL |
http://www.wjgnet.com/1007-9327/full/v19/i46/8714.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v19.i46.8714 |
