Publication Name	World Journal of Gastroenterology
Manuscript ID	5279
Country	China

Received	2013-08-27 11:17
Peer-Review Started	2013-08-27 15:39
To Make the First Decision	2013-09-09 16:57
Return for Revision	2013-09-10 11:38
Revised	2013-10-04 17:36
Second Decision	2013-10-14 09:51
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2013-10-14 13:15
Articles in Press
Publication Fee Transferred
Edit the Manuscript by Language Editor	2013-11-03 07:04
Typeset the Manuscript	2013-11-26 15:06
Publish the Manuscript Online	2013-12-18 10:39

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
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Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Autobiography
Article Title	Cooperative inhibitory effect of sinomenine combined with 5-fluorouracil on esophageal carcinoma
Manuscript Source	Invited Manuscript
All Author List	Jing Wang, Zi-Rong Yang, Wei-Guo Dong, Ji-Xiang Zhang, Xu-Feng Guo, Jia Song and Shi Qiu
Funding Agency and Grant Number
Corresponding Author	Wei-Guo Dong, MD, Department of Gastroenterology, Renmin Hospital of Wuhan University, No. 99 Zhang Zhi-dong Road, Wuhan 430060, Hubei Province, China. dwg@whu.edu.cn
Key Words	Esophageal carcinoma; Chemotherapy; Sinomenine; 5-Fluorouracil
Core Tip	The cooperative inhibitory effects of sinomenine (SIN) and 5-fluorouracil (5-FU) on esophageal carcinoma in vitro and in vivo were investigated. SIN and 5-FU alone or in combination significantly inhibited the proliferation and induced apoptosis of esophageal carcinoma cells in a dose-dependent manner. The essential mechanism underlying SIN and 5-FU-induced apoptosis, as investigated by Western blotting, involved the mitochondrial pathway. No obvious side effects were observed in the liver and kidneys of nude mice. These results indicated that the combined effects of SIN and 5-FU on esophageal carcinoma were superior to the effects of the individual compounds, without an increase in side effects.
Publish Date	2013-12-18 10:39
Citation	Wang J, Yang ZR, Dong WG, Zhang JX, Guo XF, Song J, Qiu S. Cooperative inhibitory effect of sinomenine combined with 5-fluorouracil on esophageal carcinoma. World J Gastroenterol 2013; 19(45): 8292-8300
URL	http://www.wjgnet.com/1007-9327/full/v19/i45/8292.htm
DOI	http://dx.doi.org/10.3748/wjg.v19.i45.8292

Full Article (PDF)	WJG-19-8292.pdf
Manuscript File	5279-Review.doc
Answering Reviewers	5279-Answering Reviewers.pdf
Copyright License Agreement	5279-Copyright Assignment.pdf
Non-Native Speakers of English Editing Certificate	5279-Language Certificate.pdf
Peer-review Report	5279-Peer Review(s).pdf
Scientific Editor Work List	5279-Scientific editor work list.doc