Publication Name	World Journal of Gastroenterology
Manuscript ID	5489
Country	China

Received	2013-09-10 12:22
Peer-Review Started	2013-09-12 17:00
To Make the First Decision	2013-09-27 16:26
Return for Revision	2013-10-12 11:37
Revised	2013-10-28 10:30
Second Decision	2013-11-13 11:51
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2013-11-13 14:49
Articles in Press
Publication Fee Transferred
Edit the Manuscript by Language Editor	2013-11-22 17:46
Typeset the Manuscript	2014-01-07 08:55
Publish the Manuscript Online	2014-01-26 20:08

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
Article Reprints	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Oncology
Manuscript Type	Meta-Analysis
Article Title	Combination of chemotherapy and immunotherapy for colon cancer in China: A meta-analysis
Manuscript Source	Invited Manuscript
All Author List	Zheng-Xu Wang, Jun-Xia Cao, Zhi-Ping Liu, Yu-Xin Cui, Chun-Yun Li, Duo Li, Xiao-Yan Zhang, Jin-Long Liu and Jun-Li Li
Funding Agency and Grant Number	Funding Agency Grant Number National Natural Science Foundation of China 31171427 National Natural Science Foundation of China 30971651 (to Wang ZX) National Natural Science Foundation of China 30700974 (to Cao JX) Postdoctoral Foundation of China 20060400775 (to Cao JX)
Corresponding Author	Zheng-Xu Wang, MD, PhD, Associate Professor, Director of Biotherapy Center, the General Hospital of Beijing Military Command, No.5 of Nan Men Cang Rd, Dongcheng District, Beijing 100700, China. zhxwang18@hotmail.com
Key Words	Dendritic cells; Cytokine-induced killer cells; Meta-analysis; Colon cancer; Immunotherapy
Core Tip	A growing body of knowledge on tumor immunosurveillance and loss thereof has contributed to the refinement of anti-tumor immunotherapy. The aim of our meta-analysis was to determine whether an association exists between dendritic cell (DC)-cytokine-induced killer (CIK) cell therapy combined with chemotherapy and chemotherapy alone. Our analysis demonstrates that DC-CIK therapy improved 1, 2 and 3-year overall survival, 1, 2 and 3-year disease-free survival, overall response rate and immune indices in colon cancer. In all, the combination of DC-CIK immunotherapy and chemotherapy was superior in prolonging the survival time and enhancing immunological responses, suggesting the possible application of this promising adjuvant immunotherapy in colon cancer.
Publish Date	2014-01-26 20:08
Citation	Wang ZX, Cao JX, Liu ZP, Cui YX, Li CY, Li D, Zhang XY, Liu JL, Li JL. Combination of chemotherapy and immunotherapy for colon cancer in China: A meta-analysis. World J Gastroenterol 2014; 20(4): 1095-1106
URL	http://www.wjgnet.com/1007-9327/full/v20/i4/1095.htm
DOI	http://dx.doi.org/10.3748/wjg.v20.i4.1095

Full Article (PDF)	WJG-20-1095.pdf
Full Article (Word)	WJG-20-1095.doc
Manuscript File	5489-Review.docx
Answering Reviewers	5489-Answering reviewers.pdf
Copyright License Agreement	5489-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate	5489-Language certificate.pdf
Peer-review Report	5489-Peer reviews.pdf
Scientific Editor Work List	5489-Scientific editor work list.doc