Publication Name	World Journal of Clinical Cases
Manuscript ID	60389
Country	China

Received	2020-10-27 15:51
Peer-Review Started	2020-10-27 15:52
To Make the First Decision
Return for Revision	2020-11-26 03:10
Revised	2020-12-09 01:43
Second Decision	2020-12-22 07:57
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2020-12-23 04:11
Articles in Press	2020-12-23 04:11
Publication Fee Transferred
Edit the Manuscript by Language Editor	2021-01-01 23:14
Typeset the Manuscript	2021-01-25 03:00
Publish the Manuscript Online	2021-01-30 10:10

ISSN	2307-8960 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
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Category	Infectious Diseases
Manuscript Type	Case Report
Article Title	Negative conversion of autoantibody profile in chronic hepatitis B: A case report
Manuscript Source	Unsolicited Manuscript
All Author List	Xun Zhang, Qin-Xiu Xie and Dong-Mei Zhao
ORCID	Author(s) ORCID Number Xun Zhang http://orcid.org/0000-0002-1636-6950 Qin-Xiu Xie http://orcid.org/0000-0002-3384-1274 Dong-Mei Zhao http://orcid.org/0000-0003-2559-5357
Funding Agency and Grant Number
Corresponding Author	Dong-Mei Zhao, PhD, Attending Doctor, Doctor, Department of Infectious Disease, The First Affiliated Hospital of Anhui Medical University, No. 218 Jixi Road, Hefei 230022, Anhui Province, China. zdm5460@163.com
Key Words	Autoantibodies; Autoimmune hepatitis; Chronic hepatitis B; Immune responses; Case report
Core Tip	This case involved dynamic changes in autoantibodies in the pathogenesis of hepatitis B. The patient showed positive hepatitis B surface antigen, which can cause an autoimmune phenomenon during the clearance of hepatitis B virus (HBV). Liver pathology was performed to differentiate with autoimmune hepatitis. It is possible that the virus has a role in inducing immune responses in HBV infection. This is closely related to hepatocyte injury caused by HBV infection, which is mainly mediated by immunity. Autoantibodies can appear during the course of viral hepatitis, and the combination of liver pathology and dynamic monitoring is required.
Publish Date	2021-01-30 10:10
Citation	Zhang X, Xie QX, Zhao DM. Negative conversion of autoantibody profile in chronic hepatitis B: A case report. World J Clin Cases 2021; 9(5): 1196-1203
URL	https://www.wjgnet.com/2307-8960/full/v9/i5/1196.htm
DOI	https://dx.doi.org/10.12998/wjcc.v9.i5.1196

Full Article (PDF)	WJCC-9-1196.pdf
Full Article (Word)	WJCC-9-1196.docx
Manuscript File	60389-Review-FilipodiaCL.docx
Answering Reviewers	60389-Answering reviewers.pdf
Audio Core Tip	60389-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	60389-Conflict-of-interest statement.pdf
Copyright License Agreement	60389-Copyright license agreement.pdf
Signed Informed Consent Form(s) or Document(s)	60389-Informed consent statement.pdf
Non-Native Speakers of English Editing Certificate	60389-Language certificate.pdf
Peer-review Report	60389-Peer-review(s).pdf
Scientific Misconduct Check	60389-Scientific misconduct check.pdf
Scientific Editor Work List	60389-Scientific editor work list.pdf