| ISSN |
1948-9358 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Endocrinology & Metabolism |
| Manuscript Type |
Retrospective Study |
| Article Title |
Association of β-cell function and insulin resistance with pediatric type 2 diabetes among Chinese children
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Zhen-Ran Xu, Hong-Wei Du, Lan-Wei Cui, Rong-Xiu Zheng, Gui-Mei Li, Hai-Yan Wei, Fei-Yu Lu, Li-Li Chen, Chu-Shan Wu, Shu-Xin Zhang, Shu-Le Zhang, Fang Liu, Miao-Ying Zhang, Zhou Pei, Cheng-Jun Sun, Jing Wu and Fei-Hong Luo |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Key Research and Development Program of China |
2016YFC1305302 |
| National Natural Science Fund of China |
81600608 |
| Key Research and Development Program of Shandong Province |
2017GSF18118 |
|
| Corresponding Author |
Fei-Hong Luo, MD, PhD, Chief Doctor, Department of Pediatric Endocrinology and Inherited Metabolic Diseases, National Children’s Medical Center, Children's Hospital of Fudan University, No. 399 Wan Yuan Road, Min Hang District, Shanghai 201102, China. luofh@fudan.edu.cn |
| Key Words |
Diabetes mellitus; Type 2; β-cell dysfunction; Insulin resistance; Adolescent; Homeostasis models |
| Core Tip |
This multicenter cross-sectional study described the clinical characteristics of Chinese type 2 diabetes (T2DM) children in detail, and characterized the association of β-cell function and insulin resistance with T2DM among children and adolescents. This study showed that β-cell dysfunction, compared with insulin resistance, was the stronger risk factor associated with pediatric T2DM among Chinese children, regardless of obesity status. Our results suggested that pediatricians should pay more attention to children with relatively low β-cell function regardless of insulin resistance during pediatric T2DM screening and emphasize the protection and improvement of β-cell function in T2DM children in clinical practice. |
| Publish Date |
2021-08-09 10:25 |
| Citation |
Xu ZR, Du HW, Cui LW, Zheng RX, Li GM, Wei HY, Lu FY, Chen LL, Wu CS, Zhang SX, Zhang SL, Liu F, Zhang MY, Pei Z, Sun CJ, Wu J, Luo FH. Association of β-cell function and insulin resistance with pediatric type 2 diabetes among Chinese children. World J Diabetes 2021; 12(8): 1292-1303 |
| URL |
https://www.wjgnet.com/1948-9358/full/v12/i8/1292.htm |
| DOI |
https://dx.doi.org/10.4239/wjd.v12.i8.1292 |
