| ISSN |
1948-5204 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
©The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved. |
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| Permissions |
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Pharmacology & Pharmacy |
| Manuscript Type |
Basic Study |
| Article Title |
Berberine retarded the growth of gastric cancer xenograft tumors by targeting hepatocyte nuclear factor 4α
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Ling-Li Li, Ze Peng, Qian Hu, Li-Jun Xu, Xin Zou, Dong-Mei Huang and Ping Yi |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Natural Science Foundation of China |
81673757 |
| National Natural Science Foundation of China |
81573787 |
|
| Corresponding Author |
Ping Yi, PhD, Doctor, Department of Integrated Traditional Chinese and Western Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China, Institute of Integrated Traditional Chinese and Western Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China, 1095 JieFang Avenue, Wuhan, Hubei, China., Wuhan, Hubei, China. 430030, China. pyi219@163.com |
| Key Words |
Berberine; Gastric cancer; Xenograft models; Hepatocyte nuclear factor 4α; WNT5a |
| Core Tip |
Hepatocyte nuclear factor 4α (HNF4α) is a member of the nuclear receptor transcription factor family, which is at the center of a complex transcriptional regulatory network and regulates the biological effects of different pathways via transcriptional regulation of differential target genes. The role of HNF4α in gastric cancer is poorly understood, so the study of the berberine targeting HNF4α in gastric cancer cell xenograft models is of great significance. In this study, we showed that the inhibition of HNF4α genes/proteins by berberine was correlated with the tumor inhibition in gastric cancer xenografts. Further experiments also indicated that berberine downregulated HNF4a to exert its antineoplastic activity in vivo. |
| Publish Date |
2022-04-15 09:40 |
| Citation |
Li LL, Peng Z, Hu Q, Xu LJ, Zou X, Huang DM, Yi P. Berberine retarded the growth of gastric cancer xenograft tumors by targeting hepatocyte nuclear factor 4α. World J Gastrointest Oncol 2022; 14(4): 842-857 |
| URL |
https://www.wjgnet.com/1948-5204/full/v14/i4/842.htm |
| DOI |
https://dx.doi.org/10.4251/wjgo.v14.i4.842 |
