Publication Name	World Journal of Clinical Cases
Manuscript ID	63282
Country	China

Received	2021-02-01 15:08
Peer-Review Started	2021-02-01 15:34
To Make the First Decision
Return for Revision	2021-03-07 06:31
Revised	2021-04-06 08:38
Second Decision	2021-05-18 09:05
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2021-05-18 22:40
Articles in Press	2021-05-18 22:40
Publication Fee Transferred
Edit the Manuscript by Language Editor	2021-07-02 09:29
Typeset the Manuscript	2021-08-16 01:52
Publish the Manuscript Online	2021-08-24 02:07

ISSN	2307-8960 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
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Category	Medicine, Research & Experimental
Manuscript Type	Case Report
Article Title	Aspirin-induced long-term tumor remission in hepatocellular carcinoma with adenomatous polyposis coli stopgain mutation: A case report
Manuscript Source	Unsolicited Manuscript
All Author List	Qu Lin, Ming-Jun Bai, Hao-Fan Wang, Xiang-Yuan Wu, Ming-Sheng Huang and Xing Li
ORCID	Author(s) ORCID Number Qu Lin http://orcid.org/0000-0002-4251-5577 Ming-Jun Bai http://orcid.org/0000-0002-8701-9593 Hao-Fan Wang http://orcid.org/0000-0003-2098-453X Xiang-Yuan Wu http://orcid.org/0000-0002-6765-7918 Ming-Sheng Huang http://orcid.org/0000-0003-4749-4231 Xing Li http://orcid.org/0000-0001-9145-4769
Funding Agency and Grant Number	Funding Agency Grant Number Guangzhou Science and Technology Project 201904010461 Major Talents Project of Guangdong Province 2019TQ05Y266
Corresponding Author	Xing Li, MD, Professor, Department of Medical Oncology and Guangdong Key laboratory of Liver Disease Research, The Third Affiliated Hospital of Sun Yat-sen University, No. 600 Tianhe Road, Guangzhou 510630, Guangdong Province, China. lixing9@mail.sysu.edu.cn
Key Words	Hepatocellular carcinoma; Mutation; Wnt pathway; Aspirin; Adenomatous polyposis coli; Case report
Core Tip	Hepatocellular carcinoma (HCC) is a highly heterogeneous disease. Due to the differences in etiology and ethnicities, the driving genes in HCC are likely to be different globally. Adenomatous polyposis coli (APC) mutations are critical in a fraction of HCC patients, as APC mutations might trigger HCC by activating the Wnt pathway. The effects of this mutation could be consistently suppressed by aspirin. Thus, APC mutation-triggered HCC might be a new subgroup of chronic hepatitis B virus infection-related HCC. Wnt pathway inhibition could be an effective remedy for this subgroup of patients.
Publish Date	2021-08-24 02:07
Citation	Lin Q, Bai MJ, Wang HF, Wu XY, Huang MS, Li X. Aspirin-induced long-term tumor remission in hepatocellular carcinoma with adenomatous polyposis coli stopgain mutation: A case report. World J Clin Cases 2021; 9(24): 7189-7195
URL	https://www.wjgnet.com/2307-8960/full/v9/i24/7189.htm
DOI	https://dx.doi.org/10.12998/wjcc.v9.i24.7189

Full Article (PDF)	WJCC-9-7189.pdf
Full Article (Word)	WJCC-9-7189.docx
CARE Checklist–2016	63282-CARE-Checklist–2016-revision.pdf
Manuscript File	63282_Auto_Edited-Webster J-Clear.docx
Answering Reviewers	63282-Answering reviewers.pdf
Audio Core Tip	63282-Audio core tip.m4a
Conflict-of-Interest Disclosure Form	63282-Conflict-of-interest statement.pdf
Copyright License Agreement	63282-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	63282-Grant application form(s).pdf
Signed Informed Consent Form(s) or Document(s)	63282-Informed consent statement.pdf
Non-Native Speakers of English Editing Certificate	63282-Language certificate.pdf
Supplementary Material	63282-Supplementary material.pdf
Peer-review Report	63282-Peer-review(s).pdf
Scientific Misconduct Check	63282-Scientific misconduct check.pdf
Scientific Editor Work List	63282-Scientific editor work list.pdf