Publication Name	World Journal of Clinical Oncology
Manuscript ID	63294
Country	China

Received	2021-01-27 05:42
Peer-Review Started	2021-01-27 05:49
To Make the First Decision
Return for Revision	2021-05-07 21:07
Revised	2021-05-11 07:43
Second Decision	2021-07-22 03:06
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2021-07-22 09:38
Articles in Press	2021-07-22 09:38
Publication Fee Transferred
Edit the Manuscript by Language Editor	2021-08-02 03:32
Typeset the Manuscript	2021-08-17 00:59
Publish the Manuscript Online	2021-08-23 06:43

ISSN	2218-4333 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Copyright	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license.
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Category	Oncology
Manuscript Type	Review
Article Title	Roles of microRNAs in tumorigenesis and metastasis of esophageal squamous cell carcinoma
Manuscript Source	Invited Manuscript
All Author List	Di Cui and Annie LM Cheung
ORCID	Author(s) ORCID Number Di Cui http://orcid.org/0000-0001-7095-959X Annie LM Cheung http://orcid.org/0000-0003-3217-1456
Funding Agency and Grant Number	Funding Agency Grant Number Research Grants Council of the Hong Kong SAR, China, General Research Fund 17111917
Corresponding Author	Annie LM Cheung, BSc, PhD, Associate Professor, School of Biomedical Sciences, Li Ka Shing Faculty of Medicine, University of Hong Kong, 21 Sassoon Road, Pokfulam, Hong Kong 999077, China. lmcheung@hku.hk
Key Words	MicroRNAs; Dysregulation; Tumorigenesis; Metastasis; Therapeutic potential; Esophageal squamous cell carcinoma
Core Tip	Esophageal squamous cell carcinoma (ESCC) is a deadly disease in the worldwide. Its poor prognosis is mainly due to the rapid tumor progression and high rate of invasion and metastasis. It is of great importance to understand the mechanisms underlying ESCC tumorigenesis and metastasis. Increasing studies confirmed the involvement of microRNAs (miRNAs) in cancer progression. Dysregulated miRNAs serve as possible biomarkers for ESCC diagnosis or prognosis evaluation. Moreover, miRNAs function as small post-transcriptional regulators with notable therapeutic values. This review summarized recent studies on the significance, biological functions and clinical potential of miRNAs in tumorigenesis and metastasis of ESCC.
Publish Date	2021-08-23 06:43
Citation	Cui D, Cheung AL. Roles of microRNAs in tumorigenesis and metastasis of esophageal squamous cell carcinoma. World J Clin Oncol 2021; 12(8): 609-622
URL	https://www.wjgnet.com/2218-4333/full/v12/i8/609.htm
DOI	https://dx.doi.org/10.5306/wjco.v12.i8.609

Full Article (PDF)	WJCO-12-609.pdf
Full Article (Word)	WJCO-12-609.docx
Manuscript File	63294_Auto_Edited-JPY_WangTQ.docx
Answering Reviewers	63294-Answering reviewers.pdf
Audio Core Tip	63294-Audio core tip.m4a
Conflict-of-Interest Disclosure Form	63294-Conflict-of-interest statement.pdf
Copyright License Agreement	63294-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	63294-Grant application form(s).pdf
Peer-review Report	63294-Peer-review(s).pdf
Scientific Misconduct Check	63294-Scientific misconduct check.pdf
Scientific Editor Work List	63294-Scientific editor work list.pdf