Publication Name	World Journal of Clinical Cases
Manuscript ID	63668
Country	Spain

Received	2021-04-18 18:44
Peer-Review Started	2021-04-18 18:47
To Make the First Decision
Return for Revision	2021-07-27 16:56
Revised	2021-08-26 16:47
Second Decision	2021-11-16 03:29
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2021-11-18 06:41
Articles in Press	2021-11-18 06:41
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2021-12-03 09:56
Publish the Manuscript Online	2021-12-23 14:14

ISSN	2307-8960 (online)
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Category	Gastroenterology & Hepatology
Manuscript Type	Review
Article Title	Diet and microbiome in the beginning of the sequence of gut inflammation
Manuscript Source	Invited Manuscript
All Author List	Daniel Ceballos, A Hernández-Camba and Laura Ramos
ORCID	Author(s) ORCID Number Daniel Ceballos http://orcid.org/0000-0003-2384-4524 A Hernández-Camba http://orcid.org/0000-0002-8653-207X Laura Ramos http://orcid.org/0000-0001-7015-1742
Funding Agency and Grant Number
Corresponding Author	Daniel Ceballos, MD, PhD, Assistant Professor, Chief Physician, Gastroenterology, Hospital Universitario de Gran Canaria Doctor Negrin, Barranco de La Ballena s/n - 35019 (Las Palmas), Las Palmas 35019, Canarias, Spain. dcebsan@gobiernodecanarias.org
Key Words	Diet; Microbiome; Inflammatory bowel disease; Pathogenia
Core Tip	Inflammatory bowel disease (IBD) is a chronic inflammatory condition of the gastrointestinal tract. The incidence of IBD is rising in western and newly industrialized countries, paralleling the increase of westernized dietary patterns. Microbiome is changing in western societies and can influence the activation of immune cells promoting inflammation. Change in the composition and functionality of the gut microbiome seems to be a nuclear pathogenic factor. An excessive and unhealthy consumption of sugar, animal fat and a low vegetables and fiber diet are risk factor for IBD appearance. This role of food and a reduced gut microbial diversity in cause of IBD might have also a prophylactic or therapeutic role for IBD. Dietary modulation and appropriate exclusion diets might be a new complementary management for treatment at disease flares and in refractory patients.
Publish Date	2021-12-23 14:14
Citation	Ceballos D, Hernández-Camba A, Ramos L. Diet and microbiome in the beginning of the sequence of gut inflammation. World J Clin Cases 2021; 9(36): 11122-11147
URL	https://www.wjgnet.com/2307-8960/full/v9/i36/11122.htm
DOI	https://dx.doi.org/10.12998/wjcc.v9.i36.11122

Full Article (PDF)	WJCC-9-11122.pdf
Full Article (Word)	WJCC-9-11122.docx
Manuscript File	63668_Auto_Edited.docx
Answering Reviewers	63668-Answering reviewers.pdf
Audio Core Tip	63668-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	63668-Conflict-of-interest statement.pdf
Copyright License Agreement	63668-Copyright license agreement.pdf
Non-Native Speakers of English Editing Certificate	63668-Language certificate.pdf
Peer-review Report	63668-Peer-review(s).pdf
Scientific Misconduct Check	63668-Bing-Wang LL-2.png
Scientific Editor Work List	63668-Scientific editor work list.pdf