Publication Name	World Journal of Gastroenterology
Manuscript ID	6461
Country	Italy

Received	2013-10-19 10:37
Peer-Review Started	2013-10-22 08:59
To Make the First Decision	2014-03-27 19:53
Return for Revision	2014-03-28 08:40
Revised	2014-04-02 20:53
Second Decision	2014-06-05 10:37
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2014-06-05 11:07
Articles in Press	2014-06-05 11:22
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2014-09-09 14:13
Publish the Manuscript Online	2014-10-07 17:32

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
Article Reprints	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Topic Highlights
Article Title	Probiotics against neoplastic transformation of gastric mucosa: Effects on cell proliferation and polyamine metabolism
Manuscript Source	Invited Manuscript
All Author List	Francesco Russo, Michele Linsalata and Antonella Orlando
Funding Agency and Grant Number
Corresponding Author	Francesco Russo, MD, Senior Researcher, Laboratory of Nutritional Pathophysiology, National Institute for Digestive Diseases, I.R.C.C.S. “S. de Bellis”, Via Turi 27, 70013 Castellana Grotte (Ba), Italy. francesco.russo@irccsdebellis.it
Key Words	Cell proliferation; Gastric cancer; Microbiota; Polyamines; Probiotics
Core Tip	Studies linking probiotics and gastric neoplasms have mainly been addressed to evaluate the potential of probiotics as alternative regimen against Helicobacter pylori, a carcinogen tightly connected to gastric cancer. The effects of probiotics on gastric cell proliferation are still under investigation and interest has also been paid on the polyamines metabolism. Polyamines (putrescine, spermidine and spermine) are pivotal in regulating different metabolic functions, including cell proliferation. In this review, the authors try to summarize data on gastric cancer and the proposed abilities by probiotics in affecting the gastric integrity and cell proliferation, also in relation to the polyamine metabolism.
Publish Date	2014-10-07 17:32
Citation	Russo F, Linsalata M, Orlando A. Probiotics against neoplastic transformation of gastric mucosa: Effects on cell proliferation and polyamine metabolism. World J Gastroenterol 2014; 20(37): 13258-13272
URL	http://www.wjgnet.com/1007-9327/full/v20/i37/13258.htm
DOI	http://dx.doi.org/10.3748/wjg.v20.i37.13258

Full Article (PDF)	WJG-20-13258.pdf
Full Article (Word)	WJG-20-13258.doc
Manuscript File	6461-Review.doc
Answering Reviewers	6461-Answering reviewers.pdf
Copyright License Agreement	6461-Copyright assignment.pdf
Peer-review Report	6461-Peer review(s).pdf
Scientific Misconduct Check	6461-CrossCheck.jpg
Scientific Editor Work List	6461-Scientific editor work list.pdf