Publication Name	World Journal of Hepatology
Manuscript ID	64652
Country	France

Received	2021-02-23 17:19
Peer-Review Started	2021-02-23 17:27
To Make the First Decision
Return for Revision	2021-05-03 00:59
Revised	2021-05-04 06:42
Second Decision	2021-08-05 03:21
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2021-08-05 08:37
Articles in Press	2021-08-05 08:37
Publication Fee Transferred
Edit the Manuscript by Language Editor	2021-08-14 18:41
Typeset the Manuscript	2021-09-16 10:49
Publish the Manuscript Online	2021-09-22 08:09

ISSN	1948-5182 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Copyright	© The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Biology
Manuscript Type	Review
Article Title	Epigenetic mechanisms of liver tumor resistance to immunotherapy
Manuscript Source	Invited Manuscript
All Author List	Julie Sanceau and Angélique Gougelet
ORCID	Author(s) ORCID Number Julie Sanceau http://orcid.org/0000-0002-6621-2730 Angélique Gougelet http://orcid.org/0000-0001-7464-9804
Funding Agency and Grant Number	Funding Agency Grant Number Ligue Nationale Contre le Cancer and the Agence Nationale de la Recherche DLK1-EPILIV 2018-2021 Université de Paris
Corresponding Author	Angélique Gougelet, PhD, Research Scientist, Centre de Recherche des Cordeliers, Sorbonne Université, Inserm, Université de Paris, 15 Rue de L'école de Médecine, Paris 75006, France. angelique.gougelet@inserm.fr
Key Words	Liver cancer; Immunotherapies; Epigenetics; Resistance; Hepatocellular carcinoma
Core Tip	Although our understanding of hepatocellular carcinoma (HCC) pathogenesis has improved, this aggressive tumor is still devoid of effective treatments and remains a major health problem. Despite the justified hopes on immunotherapies, only a limited number of HCC patients respond to treatments. The characterization of the molecular mechanisms displayed by tumor cells to evade immune response will help to consider new combinations of therapies. The recent years, growing body of evidence argue for a modulation of tumor immune privilege by several epigenetic events and renders drugs targeting these regulators as a partner of choice for immunotherapy combination strategies.
Publish Date	2021-09-22 08:09
Citation	Sanceau J, Gougelet A. Epigenetic mechanisms of liver tumor resistance to immunotherapy. World J Hepatol 2021; 13(9): 979-1002
URL	https://www.wjgnet.com/1948-5182/full/v13/i9/979.htm
DOI	https://dx.doi.org/10.4254/wjh.v13.i9.979

Full Article (PDF)	WJH-13-979.pdf
Full Article (Word)	WJH-13-979.docx
Manuscript File	64652-Review-Filipodia.docx
Answering Reviewers	64652-Answering reviewers.pdf
Audio Core Tip	64652-Audio core tip.m4a
Conflict-of-Interest Disclosure Form	64652-Conflict-of-interest statement.pdf
Copyright License Agreement	64652-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	64652-Grant application form(s).pdf
Non-Native Speakers of English Editing Certificate	64652-Language certificate.pdf
Peer-review Report	64652-Peer-review(s).pdf
Scientific Misconduct Check	64652-Bing-Wang JL-1.jpg
Scientific Misconduct Check	64652-Scientific misconduct check.pdf
Scientific Editor Work List	64652-Scientific editor work list.pdf