Publication Name	World Journal of Gastrointestinal Oncology
Manuscript ID	64949
Country	Germany

Received	2021-02-25 17:21
Peer-Review Started	2021-02-25 17:30
To Make the First Decision
Return for Revision	2021-04-19 04:34
Revised	2021-04-30 15:29
Second Decision	2021-08-16 03:31
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2021-08-16 08:08
Articles in Press	2021-08-16 08:08
Publication Fee Transferred
Edit the Manuscript by Language Editor	2021-09-15 20:08
Typeset the Manuscript	2021-11-05 10:24
Publish the Manuscript Online	2021-11-12 11:22

ISSN	1948-5204 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
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Category	Oncology
Manuscript Type	Review
Article Title	Role of mammalian target of rapamycin complex 2 in primary and secondary liver cancer
Manuscript Source	Invited Manuscript
All Author List	Katharina Joechle, Jessica Guenzle, Claus Hellerbrand, Pavel Strnad, Thorsten Cramer, Ulf Peter Neumann and Sven Arke Lang
ORCID	Author(s) ORCID Number Katharina Joechle http://orcid.org/0000-0001-9120-1526 Jessica Guenzle http://orcid.org/0000-0001-6008-3731 Claus Hellerbrand http://orcid.org/0000-0001-9472-4461 Pavel Strnad http://orcid.org/0000-0002-7122-6379 Thorsten Cramer http://orcid.org/0000-0002-6462-239X Ulf Peter Neumann http://orcid.org/0000-0002-3831-8917 Sven Arke Lang http://orcid.org/0000-0003-4455-5676
Funding Agency and Grant Number	Funding Agency Grant Number Deutsche Forschungsgemeinschaft (DFG) FOR2127; LA1988/4-2
Corresponding Author	Sven Arke Lang, FEBS, MD, Professor, Senior Researcher, Surgeon, Department of General, Visceral and Transplantation Surgery, University Hospital Rheinisch-Westfälisch Technische Hochschule Aachen, Pauwelsstrasse 30, Aachen 52074, Germany. svlang@ukaachen.de
Key Words	Mammalian target of rapamycin; Mammalian target of rapamycin complex 2; Rictor; Liver cancer; Liver metastases; Hepatocellular carcinoma; Cholangiocellular carcinoma
Core Tip	Lately, mammalian target of rapamycin complex 2 (mTORC2) has gained importance in cancer research as it is one of the key effectors of the PI3K/AKT/mTOR pathway and stimulates cell growth, cell survival, metabolism and cytoskeletal organization. Rictor, the central subunit of mTORC2, was found to be upregulated in different kind of cancers and associated with a bad prognosis. We herein discuss the implications of mTORC2 in primary and secondary liver cancer.
Publish Date	2021-11-12 11:22
Citation	Joechle K, Guenzle J, Hellerbrand C, Strnad P, Cramer T, Neumann UP, Lang SA. Role of mammalian target of rapamycin complex 2 in primary and secondary liver cancer. World J Gastrointest Oncol 2021; 13(11): 1632-1647
URL	https://www.wjgnet.com/1948-5204/full/v13/i11/1632.htm
DOI	https://dx.doi.org/10.4251/wjgo.v13.i11.1632

Full Article (PDF)	WJGO-13-1632.pdf
Full Article (Word)	WJGO-13-1632.docx
Manuscript File	64949-Review-Filipodia-CL.docx
Answering Reviewers	64949-Answering reviewers.pdf
Audio Core Tip	64949-Audio core tip.m4a
Conflict-of-Interest Disclosure Form	64949-Conflict-of-interest statement.pdf
Copyright License Agreement	64949-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	64949-Grant application form(s).pdf
Non-Native Speakers of English Editing Certificate	64949-Language certificate.pdf
Peer-review Report	64949-Peer-review(s).pdf
Scientific Misconduct Check	64949-Bing-Wang LL-2.png
Scientific Misconduct Check	64949-Scientific misconduct check.pdf
Scientific Editor Work List	64949-Scientific editor work list.pdf