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Articles Published Processes
8/18/2021 8:08:20 AM | Browse: 344 | Download: 800
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Received |
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2021-03-03 13:55 |
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Peer-Review Started |
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2021-03-03 13:59 |
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To Make the First Decision |
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Return for Revision |
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2021-04-17 13:53 |
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Revised |
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2021-05-01 20:08 |
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Second Decision |
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2021-08-09 02:29 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Company Editor-in-Chief |
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2021-08-09 09:02 |
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Articles in Press |
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2021-08-09 09:02 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2021-08-12 02:03 |
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Publish the Manuscript Online |
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2021-08-18 08:08 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Retrospective Study |
| Article Title |
Histological differentiation impacts the tumor immune microenvironment in gastric carcinoma: Relation to the immune cycle
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Artem Mashukov, Dmytro Shapochka, Oleksii Seleznov, Nazarii Kobyliak, Tetyana Falalyeyeva, Stanislav Kirkilevsky, Roman Yarema and Oksana Sulaieva |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Nazarii Kobyliak, PhD, Associate Professor, Department of Endocrinology, Bogomolets National Medical University, Pushkinska 22a str., Kyiv 01601, Ukraine. nazariikobyliak@gmail.com |
| Key Words |
Gastric carcinoma; Tumor immune microenvironment; Tumor infiltrating lymphocytes; Tumor associated macrophages |
| Core Tip |
In this study, we investigated the tumor-host interplay in gastric carcinoma (GC) through the tumor immune cycle concept. Histologically different GCs vary in immunogenicity and differ in tumor-infiltrating lymphocyte and macrophage densities. Intestinal GC demonstrated predominantly inflamed tumor immune microenvironment and frequent programmed death-ligand 1 expression. In contrast, more aggressive diffuse and mucinous GCs possessed low immunogenicity with a lack of cancer antigen recognition and trafficking. These data help to clarify the links between tumor histogenesis and immunogenicity, offering a better understanding of GC biology and the ability to provide more tailored patient management. |
| Publish Date |
2021-08-18 08:08 |
| Citation |
Mashukov A, Shapochka D, Seleznov O, Kobyliak N, Falalyeyeva T, Kirkilevsky S, Yarema R, Sulaieva O. Histological differentiation impacts the tumor immune microenvironment in gastric carcinoma: Relation to the immune cycle. World J Gastroenterol 2021; 27(31): 5259-5271 |
| URL |
https://www.wjgnet.com/1007-9327/full/v27/i31/5259.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v27.i31.5259 |
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