Publication Name	World Journal of Gastroenterology
Manuscript ID	65660
Country	Italy

Received	2021-03-12 12:49
Peer-Review Started	2021-03-12 12:55
To Make the First Decision
Return for Revision	2021-04-17 05:07
Revised	2021-04-29 15:08
Second Decision	2021-09-03 03:06
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2021-09-03 06:50
Articles in Press	2021-09-03 06:50
Publication Fee Transferred
Edit the Manuscript by Language Editor	2021-09-15 10:24
Typeset the Manuscript	2021-10-08 00:22
Publish the Manuscript Online	2021-10-12 06:53

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
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Category	Pharmacology & Pharmacy
Manuscript Type	Editorial
Article Title	Biomarkers for gastrointestinal adverse events related to thiopurine therapy
Manuscript Source	Invited Manuscript
All Author List	Giulia Zudeh, Raffaella Franca, Gabriele Stocco and Giuliana Decorti
ORCID	Author(s) ORCID Number Giulia Zudeh http://orcid.org/0000-0001-6168-5662 Raffaella Franca http://orcid.org/0000-0001-8569-2023 Gabriele Stocco http://orcid.org/0000-0003-0964-5879 Giuliana Decorti http://orcid.org/0000-0002-9714-6246
Funding Agency and Grant Number
Corresponding Author	Gabriele Stocco, PhD, Associate Professor, Department of Life Sciences, University of Trieste, via Fleming 22, Trieste 34127, Italy. stoccog@units.it
Key Words	Thiopurines; Gastrointestinal adverse effects; Biomarkers; PACSIN2; RAC1; ITPA
Core Tip	Adverse reactions to thiopurines are one of the main causes of treatment discontinuation or interruption. In addition to myelosuppression, approximately 5–20% of patients develop gastrointestinal toxicity; the identification of biomarkers to prevent and/or monitor these adverse reactions is important for the proactive management of long-term thiopurine therapy. In this editorial, we discuss evidence supporting the use of PACSIN2, RAC1 and ITPA genes, in addition to TPMT and NUDT15, as possible biomarkers of thiopurine-related gastrointestinal toxicity.
Publish Date	2021-10-12 06:53
Citation	Zudeh G, Franca R, Stocco G, Decorti G. Biomarkers for gastrointestinal adverse events related to thiopurine therapy. World J Gastroenterol 2021; 27(38): 6348-6356
URL	https://www.wjgnet.com/1007-9327/full/v27/i38/6348.htm
DOI	https://dx.doi.org/10.3748/wjg.v27.i38.6348

Full Article (PDF)	WJG-27-6348.pdf
Full Article (Word)	WJG-27-6348.docx
Manuscript File	65660_Auto_Edited-JPY_WangTQ.docx
Answering Reviewers	65660-Answering reviewers.pdf
Audio Core Tip	65660-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	65660-Conflict-of-interest statement.pdf
Copyright License Agreement	65660-Copyright license agreement.pdf
Non-Native Speakers of English Editing Certificate	65660-Language certificate.pdf
Peer-review Report	65660-Peer-review(s).pdf
Scientific Misconduct Check	65660-Scientific misconduct check.pdf
Scientific Editor Work List	65660-Scientific editor work list.pdf