Publication Name	World Journal of Clinical Cases
Manuscript ID	65984
Country	Romania

Received	2021-03-18 20:31
Peer-Review Started	2021-03-18 20:36
To Make the First Decision
Return for Revision	2021-06-06 12:21
Revised	2021-06-14 08:11
Second Decision	2021-07-05 12:47
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2021-07-05 13:14
Articles in Press	2021-07-05 13:14
Publication Fee Transferred
Edit the Manuscript by Language Editor	2021-07-10 21:29
Typeset the Manuscript	2021-08-02 00:44
Publish the Manuscript Online	2021-08-05 14:37

ISSN	2307-8960 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
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Category	Pediatrics
Manuscript Type	Case Control Study
Article Title	Innate immunity – the hallmark of Helicobacter pylori infection in pediatric chronic gastritis
Manuscript Source	Invited Manuscript
All Author List	Lorena Elena Meliț, Cristina Oana Mărginean, Maria Oana Săsăran, Simona Mocan, Dana Valentina Ghiga, Alina Bogliş and Carmen Duicu
ORCID	Author(s) ORCID Number Lorena Elena Meliț http://orcid.org/0000-0001-8857-2289 Cristina Oana Mărginean http://orcid.org/0000-0003-2119-1726 Maria Oana Săsăran http://orcid.org/0000-0001-8156-7460 Simona Mocan http://orcid.org/0000-0001-8067-5072 Dana Valentina Ghiga http://orcid.org/0000-0003-4185-606X Alina Bogliş http://orcid.org/0000-0001-9025-0959 Carmen Duicu http://orcid.org/0000-0002-8056-1339
Funding Agency and Grant Number	Funding Agency Grant Number University of Medicine, Pharmacy, Sciences and Technology “George Emil Palade” of Târgu Mureș, Romania 293/6/14.01.2020
Corresponding Author	Cristina Oana Mărginean, MD, PhD, Professor, Department of Pediatrics I, “George Emil Palade” University of Medicine, Pharmacy, Sciences and Technology Târgu Mureș, Gheorghe Marinescu Street No. 38, Targu Mures 540136, Romania. marginean.oana@gmail.com
Key Words	Innate immunity; Helicobacter pylori infection; Children; Chronic gastritis; TLR9; Systemic inflammation
Core Tip	Environmental factors, such as poor living conditions and rural area might result in an increased risk for Helicobacter pylori (H. pylori) chronic gastritis in children. Serological and rapid urease tests could be used as reliable tests for the detection of H. pylori infection in children. Moreover, leukocytes and neutrophils are important non-invasive biomarkers for detecting the low-grade inflammatory status associated with this infection in pediatric patients. In terms of innate immunity, our findings emphasized that variant TT genotype carriers of the TLR9 rs352140 gene polymorphism might express a more severe degree of inflammation.
Publish Date	2021-08-05 14:37
Citation	Meliț LE, Mărginean CO, Săsăran MO, Mocan S, Ghiga DV, Bogliş A, Duicu C. Innate immunity – the hallmark of Helicobacter pylori infection in pediatric chronic gastritis . World J Clin Cases 2021; 9(23): 6686-6697
URL	https://www.wjgnet.com/2307-8960/full/v9/i23/6686.htm
DOI	https://dx.doi.org/10.12998/wjcc.v9.i23.6686

Full Article (PDF)	WJCC-9-6686.pdf
Full Article (Word)	WJCC-9-6686.docx
Manuscript File	65984_Review-FilipodiaCL.docx
Answering Reviewers	65984-Answering reviewers.pdf
Audio Core Tip	65984-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	65984-Conflict-of-interest statement.pdf
Copyright License Agreement	65984-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	65984-Grant application form(s).pdf
Signed Informed Consent Form(s) or Document(s)	65984-Informed consent statement.pdf
Institutional Review Board Approval Form or Document	65984-Institutional review board statement.pdf
Peer-review Report	65984-Peer-review(s).pdf
Scientific Misconduct Check	65984-Scientific misconduct check.pdf
Scientific Editor Work List	65984-Scientific editor work list.pdf