Publication Name	World Journal of Gastrointestinal Surgery
Manuscript ID	66003
Country	Italy

Received	2021-03-20 22:46
Peer-Review Started	2021-03-20 22:49
To Make the First Decision
Return for Revision	2021-10-04 14:01
Revised	2021-10-18 17:35
Second Decision	2022-01-24 03:56
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2022-01-25 03:20
Articles in Press	2022-01-25 03:20
Publication Fee Transferred
Edit the Manuscript by Language Editor	2022-01-17 23:33
Typeset the Manuscript	2022-02-18 02:23
Publish the Manuscript Online	2022-02-22 14:13

ISSN	1948-9366 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
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Category	Gastroenterology & Hepatology
Manuscript Type	Frontier
Article Title	Therapeutic strategies for gastro-entero-pancreatic neuroendocrine neoplasms: State-of-the-art and future perspectives
Manuscript Source	Invited Manuscript
All Author List	Elettra Merola, Andrea Michielan, Umberto Rozzanigo, Marco Erini, Sandro Sferrazza, Stefano Marcucci, Chiara Sartori, Chiara Trentin, Giovanni de Pretis and Franca Chierichetti
ORCID	Author(s) ORCID Number Elettra Merola http://orcid.org/0000-0001-9553-7684 Andrea Michielan http://orcid.org/0000-0003-1353-0935 Umberto Rozzanigo http://orcid.org/0000-0002-9541-2555 Marco Erini http://orcid.org/0000-0002-6314-0196 Sandro Sferrazza http://orcid.org/0000-0002-7595-0129 Stefano Marcucci http://orcid.org/0000-0001-9144-9038 Chiara Sartori http://orcid.org/0000-0003-3137-0082 Chiara Trentin http://orcid.org/0000-0002-5213-0208 Giovanni de Pretis http://orcid.org/0000-0001-7636-0422 Franca Chierichetti http://orcid.org/0000-0002-1898-4736
Funding Agency and Grant Number
Corresponding Author	Elettra Merola, MD, PhD, N/A, Department of Gastroenterology, Santa Chiara Hospital, Azienda Provinciale per i Servizi Sanitari (APSS), Largo Medaglie D’Oro 9, Trento 38122, Italy. elettra.merola@apss.tn.it
Key Words	Gastro-entero-pancreatic neuroendocrine neoplasms; Therapeutic strategies; Radical surgery; Medical treatments; Overview; Future perspectives
Core Tip	Gastro-entero-pancreatic neuroendocrine neoplasms (GEP-NENs) have shown an increasing incidence over the past few decades. Although International Guidelines propose algorithms aimed at guiding therapeutic strategies, the need for personalized treatment continues to increase. Radical resection is always the best option when feasible, however up to 80% of cases are metastatic upon diagnosis. Several medical therapies are available for unresectable cases: Somatostatin analogs, peptide receptor radionuclide therapy, targeted drugs (primarily Everolimus and Sunitinib), chemotherapy and immunotherapy. This review provides an updated overview of the available therapeutic options for GEP-NENs and attempts to discuss future perspectives in this field.
Publish Date	2022-02-22 14:13
Citation	Merola E, Michielan A, Rozzanigo U, Erini M, Sferrazza S, Marcucci S, Sartori C, Trentin C, de Pretis G, Chierichetti F. Therapeutic strategies for gastro-entero-pancreatic neuroendocrine neoplasms: State-of-the-art and future perspectives. World J Gastrointest Surg 2022; 14(2): 78-106
URL	https://www.wjgnet.com/1948-9366/full/v14/i2/78.htm
DOI	https://dx.doi.org/10.4240/wjgs.v14.i2.78

Full Article (PDF)	WJGS-14-78.pdf
Full Article (Word)	WJGS-14-78.docx
Manuscript File	66003_Auto_Edited-JRF-Filipodia CL.doc
Answering Reviewers	66003-Answering reviewers.pdf
Audio Core Tip	66003-Audio core tip.m4a
Conflict-of-Interest Disclosure Form	66003-Conflict-of-interest statement.pdf
Copyright License Agreement	66003-Copyright license agreement.pdf
Non-Native Speakers of English Editing Certificate	66003-Language certificate.pdf
Supplementary Material	66003-Supplementary material.pdf
Peer-review Report	66003-Peer-review(s).pdf
Scientific Misconduct Check	66003-Bing-Fan JR-2.png
Scientific Editor Work List	66003-Scientific editor work list.pdf