| ISSN |
2150-5330 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
©The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
|
| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
|
| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Medicine, Research & Experimental |
| Manuscript Type |
Clinical and Translational Research |
| Article Title |
Chemokine receptor 8 expression may be linked to disease severity and elevated interleukin 6 secretion in acute pancreatitis
|
| Manuscript Source |
Invited Manuscript |
| All Author List |
Mwangala Nalisa, Ekene Emmanuel Nweke, Martin D Smith, Jones Omoshoro-Jones, John WS Devar, Rebecca Metzger, Tanya N Augustine and Pascaline N Fru |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Research Foundation |
121277 |
| University of the Witwatersrand Individual Grant |
001283844110151211055142 |
| University of the Witwatersrand Faculty of Health Sciences Seed Funding |
0012518441101512110500000000000000004550 |
|
| Corresponding Author |
Pascaline N Fru, BSc, MSc, PhD, Senior Scientist, Department of Surgery, School of Clinical Medicine, Faculty of Health Sciences, University of the Witwatersrand, 7 York Road, Parktown, Johannesburg 2193, Gauteng, South Africa. pascaline.fru@wits.ac.za |
| Key Words |
Acute Pancreatitis; Severity; Stratification, Interleukin-6; Chemokine Receptor 8; Lymphocytes; Monocytes |
| Core Tip |
Chemokine receptor 8 (CCR8) is a chemokine receptor that is highly expressed on monocytes and cells of T helper type-2 (Th2) lineage including innate lymphoid cells group 2 and 3 (ILC2 and 3). This study shows possible linkages between increasing CCR8 expression and severity in mainly moderately severe acute pancreatitis (MSAP) patients when compared to mild acute pancreatitis (MAP). Differing lymphocyte and monocyte cell frequencies suggest that in MAP, interleukin (IL)-6 was highly expressed in lymphocytes, and the severe patients [MSAP and severe acute pancreatitis (SAP)] were highly expressed by monocytes. The findings open doors for future work, which could include an in-depth look at IL-6 producing cells such as Th2 Lymphocytes, monocytes, and innate ILC2 to determine cell-associated cytokine as a novel approach in prognosticating AP disease severity. |
| Publish Date |
2021-11-16 09:46 |
| Citation |
Nalisa M, Nweke EE, Smith MD, Omoshoro-Jones J, Devar JW, Metzger R, Augustine TN, Fru PN. Chemokine receptor 8 expression may be linked to disease severity and elevated interleukin 6 secretion in acute pancreatitis. World J Gastrointest Pathophysiol 2021; 12(6): 115-129 |
| URL |
https://www.wjgnet.com/2150-5330/full/v12/i6/115.htm |
| DOI |
https://dx.doi.org/10.4291/wjgp.v12.i6.115 |
