| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Oncology |
| Manuscript Type |
Retrospective Cohort Study |
| Article Title |
MTNR1B polymorphisms with CDKN2A and MGMT methylation status are associated with poor prognosis of colorectal cancer in Taiwan
|
| Manuscript Source |
Invited Manuscript |
| All Author List |
Chia-Cheng Lee, Yu-Cheng Kuo, Je-Ming Hu, Pi-Kai Chang, Chien-An Sun, Tsan Yang, Chuan-Wang Li, Chao-Yang Chen, Fu-Huang Lin, Chih-Hsiung Hsu and Yu-Ching Chou |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Ministry of National Defense-Medical Affairs Bureau, Taiwan |
MND-MAB-110-109 |
| Ministry of National Defense-Medical Affairs Bureau, Taiwan |
MND-MAB-D-111059 |
|
| Corresponding Author |
Yu-Ching Chou, PhD, Professor, School of Public Health, National Defense Medical Center, No. 161 Sec. 6, Minquan E. Road, Neihu District, Taipei 114, Taiwan. trishow@mail.ndmctsgh.edu.tw |
| Key Words |
Colorectal cancer; Melatonin; Hypermethylation; Polymorphism; Prognosis; Biomarker |
| Core Tip |
In this retrospective cohort study, we found that MTNR1B single-nucleotide polymorphism were associated with a significantly increased risk of colorectal cancer (CRC) 5-year overall survival. A strong cumulative effect of the four polymorphisms on CRC prognosis was observed. This study indicated the novel genetic biomarkers, MTNR1B, combined with CDKN2A and MGMT gene methylation statuses, maybe a predictive tool for CRC prognosis. |
| Publish Date |
2021-09-09 06:46 |
| Citation |
Lee CC, Kuo YC, Hu JM, Chang PK, Sun CA, Yang T, Li CW, Chen CY, Lin FH, Hsu CH, Chou YC. MTNR1B polymorphisms with CDKN2A and MGMT methylation status are associated with poor prognosis of colorectal cancer in Taiwan. World J Gastroenterol 2021; 27(34): 5737-5752 |
| URL |
https://www.wjgnet.com/1007-9327/full/v27/i34/5737.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v27.i34.5737 |
